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COVID-19 Therapeutic Misinformation and Toxicological Consequences
Mohammad Amrollahi-Sharifabadi

Mohammad Amrollahi-Sharifabadi

January 31, 2024
The new coronavirus pandemic alarmed the world. Misinformation regarding prevention and treatment for safeguarding against this pandemic seemed to be life-threatening along with the spreading pandemic. Public health authorities in the world tried to battle this virtual virus by offering true information and correcting misinformation. However, the public misinformation through social media caused toxicological consequences in some parts of the world which provoked awareness, response, and concern of the public health authorities including the FDA and toxicology community. On the other hand, finding new strategies for the prevention and treatment of the coronavirus again stress the roles of public education about true drug information. Hundreds of chemicals were/are being tested to be prophylactic medications or healing drugs for the coronavirus. Therefore, spread accurate information and edit misinformation can be crucial. This essay is going to bring the attention of misinformation regarding prevention and treatment for safeguarding against the COVID-19 pandemic and its toxicological consequences and the need for public education toward appropriate use of therapies.
Quantification of Aspergillus fumigatus antigen Asp f 1 in airway tissue and allergic...
Yui Miyabe
Hiroki Tomizawa

Yui Miyabe

and 11 more

January 31, 2024
Background: In allergic inflammation, the cells existing in the mucosa take up antigens and present them to produce specific IgE, but there is no clinical study that quantifies antigens that cause allergies in local tissues. Fungi can induce the formation of nasal polyps via epithelial damage and type-2 inflammation. Aspergillus fumigatus is the most common environmental allergen; however, the involvement of its specific antigens in local allergic reactions in nasal polyps has not yet been reported. Objective: To investigate local allergic reactions to the Aspergillus fumigatus antigen, Asp f 1 in patients with CRSwNP. Materials and Methods: Nasal polyp tissues were collected from 103 patients with CRSwNP during surgery and homogenized. Tissue eosinophil counts and Asp f1, Aspergillus-specific IgE, type 2 cytokines and galectin-10 levels were measured in nasal polyps. Results: Eighteen cases (15.9%) of 103 patients were positive for Asp f 1 and were divided into two groups based on Asp f 1 levels. Asp f 1 levels positively correlated with Aspergillus-specific IgE levels (r =0.68, p <0.01). Aspergillus-specific IgE (p <0.01) levels in nasal polyps were significantly higher in the high Asp f 1 group than in the low Asp f 1 group although no significant differences were observed in IgM levels between these groups. Furthermore, Asp f 1 levels positively correlated with tissue IL-4 levels (r =0.85, p <0.0005) or tissue galectin-10 levels (r =0.54, p<0.01). Conclusion: This is the first study to quantify the levels of Aspergillus fumigatus antigen in the nasal polyps of patients with CRSwNP. The presence of Asp f 1 might explain the local type 2 allergic reaction to Aspergillus fumigatus in CRSwNP.
Exponential convex functions with respect to s and Hermite-Hadamard type inequalities
Mahir KADAKAL

Mahir KADAKAL

January 31, 2024
In this paper, we study the concept of exponential convex functions with respect to s and prove Hermite-Hadamard type inequalities for the newly introduced this class of functions. In addition, we get some refinements of the Hermite-Hadamard inequality for functions whose first derivative in absolute value, raised to a certain power which is greater than one, respectively at least one, is exponential convex with respect to s. Our results coincide with the results obtained previously in special cases.
Dynamic behaviors of abundant solutions for the Lakshmanan--Porsezian--Daniel equatio...
Handong Guo
Tiecheng Xia

Han-Dong Guo

and 2 more

January 31, 2024
The integrable Lakshmanan–Porsezian–Daniel (LPD) equation originating in nonlinear fiber is studied in this work via the Riemann–Hilbert (RH) approach. Firstly we perform the spectral analysis of the Lax pair along with LPD equation, from which a RH problem is formulated. Afterwards, using the symmetry relations of the potential matrix, the formula of N-soliton solutions can be obtained by solving the special RH problem with reflectionless under the conditions of irregularity. In particular, the localized structures and dynamic behaviors of the breathers and solitons corresponding to the real part, imaginary part and modulus of the resulting solution r(x,t) are shown graphically and discussed in detail. One of the innovations in the paper is that the higher-order linear and nonlinear term β has important impact on the velocity, phase, period, and wavewidth of wave dynamics. The other is that collisions of the high-order breathers and soliton solutions are elastic interaction which imply they remain bounded all the time.
Algebras of Mellin pseudodifferential operators with quasicontinuous symbols.
Yuri Karlovich

Yuri Karlovich

January 31, 2024
The paper deals with studying a Banach algebra ${\mathfrak D}_p$ generated by Mellin pseudodifferential operators with a subclass $\widehat{\mathcal E}(\mathbb{R}_+, \!V(\mathbb{R}))$ of quasicontinuous $V(\mathbb{R})$-valued symbols on Lebesgue spaces $L^p(\mathbb{R}_+,d\mu)$, where $V(\mathbb{R})$ is the Banach algebra of absolutely continuous functions of bounded total variation on the real line $\mathbb{R}$, $p\in(1,\infty)$ and $d\mu(r)=dr/r$. Constructing approximations of symbols ${\mathfrak a}\in\widehat{\mathcal E} (\mathbb{R}_+,V(\mathbb{R}))$ by functions similar to symbols of singular integral operators with quasicontinuous coefficients, which form a Banach algebra ${\mathfrak A}_p$, the similarity of the algebras ${\mathfrak D}_p$ and ${\mathfrak A}_p$ is established, and the compactness of commutators and semicommutators of Mellin pseudodifferential operators $\operatorname{Op}({\mathfrak a})\in{\mathfrak D}_p$ with symbols ${\mathfrak a} \in\widehat{\mathcal E}(\mathbb{R}_+,V(\mathbb{R}))$ is proved. A Fredholm symbol calculus for the Banach algebra ${\mathfrak D}_p$ is constructed and a Fredholm criterion and an index formula for the operators $D\in{\mathfrak D}_p$ are obtained.
Inferior clinical outcomes of pediatric rhabdomyosarcoma in Thailand: A 16-year exper...
Polypailin Preechawetchakul
Songyos Rajborirug

Polypailin Preechawetchakul

and 5 more

January 31, 2024
Abstract Background: There is limited data available on the treatment outcomes of pediatric rhabdomyosarcoma (RMS) in Asian populations. Therefore, we aimed to review the baseline characteristics, clinical outcomes, and prognostic factors in children with RMS from Thailand. Methods: The data of children under 15 years of age diagnosed with RMS between 2003 and 2019 from a large tertiary hospital in Southern Thailand were retrospectively reviewed. Descriptive statistics were utilized to describe the clinical characteristics. The Kaplan–Meier method was utilized to estimate survival. Cox proportional hazards regression analysis was utilized to determine prognostic factors that affect survival. Results: A total of 42 children RMS were included in this study. The median age at diagnosis was 6.4 years (IQR, 2.4–10.2). Among these patients, 11 (26%) were older than 10 years, and 13 (31%) presented with metastatic disease at diagnosis. The 5-year overall survival (OS) rate was 39% for all children. Age greater than 10 years (hazard ratio (HR): 3.3, 95% CI: 1.2–9.2) and metastatic disease at diagnosis (hazard ratio (HR): 2.8, 95% CI: 1.1–7.5) were independently associated with poorer survival. The 3-year OS for children with metastatic disease (stage IV) was 15% (95% CI: 4.3–55). Conclusion: The percentage of metastatic disease in our cohort was higher than that in previous reports and may have contributed to a poorer outcome. Age greater than 10 years and metastatic disease at diagnosis were noted as adverse prognostic factors.
Normal values for maximal respiratory pressures in children and adolescents: a system...
Nicole Pradi
Danielle Soares Rocha Vieira

Nicole Pradi

and 8 more

January 31, 2024
Objective: To present normative values for maximal respiratory pressures in healthy children and adolescents based on a meta-analysis of reference equations from previous publications. Data Sources: The searches were carried out until May 2020 in the following databases: ScienceDirect, Medical Literature Analysis and Retrieval System Online- MEDLINE (PubMed), Cumulative Index to Nursing and Allied Health Literature - CINAHL, Scientific Electronic Library Online - SciELO. Study Selection: Articles that determined normative values and/or reference equations for maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) in healthy children and adolescents published in English, Portuguese, or Spanish regardless of the year of publication were included. Data Extraction: Two reviewers selected titles and abstracts to identify the studies. In case of conflict, a third reviewer was requested. Results: Initially, 248 studies were identified, 26 studies were included in the systematic review and 17 in the meta-analysis. The sample consisted of 5,190 individuals, and the MIP and MEP values were stratified by sex and age groups of 4-11 and 12-19 years. Values from 4 to 11 years for females were: 66.4 cmH2O for MIP and 74.8 cmH2O for MEP, and for males, 76.1 cmH2O for MIP and 84.7 cmH2O for MEP. In the age group from 12 to 19 years, for females were: 81.4 cmH2O for MIP and 90.1 cmH2O for MEP, and for males were 95.6 cmH2O for MIP and 108.3 cmH2O for MEP. Conclusions: This meta-analysis suggested normative values for respiratory muscle strength in children and adolescents based on 17 studies.
The effectiveness of post-professional physical therapist training in the treatment o...
Carolyn Cheema
Jonathan Baldwin

Carolyn Cheema

and 9 more

January 31, 2024
Rationale Low back pain (LBP) is a leading cause of disability in the United States creating substantial economic hardship through multiple negative social, financial, and health effects. Chronic low back pain (CLBP) accounted for just above half of patients treated in physical therapy (PT) clinics for LBP. However, a systematic review and meta-analysis showed only small benefit from PT in the treatment of CLBP. Preliminary evidence suggests that clinician-level variables such as post-professional education may affect treatment outcomes, but requires further investigation to determine whether patients with CLBP would reap greater benefit from treatment by providers with post-professional training. This study examined the relationship between levels of clinician training and patient-reported outcomes in the treatment of CLBP. Methods PTs were surveyed using a large commercial patient outcome assessment system to determine their level of post-professional education then categorized by education level. Outcomes for 2497 patients with CLBP were extracted from the database. To account for the possibility that clinicians with higher levels of training are referred more clinically complex patients, a machine learning approach was used to identify predictive variables for clinician group, which were then used to construct propensity scores as a means to account for differences between groups. Differences in functional status score change among the pooled data were analyzed using linear models adjusted for propensity scores. Results There were no clinically meaningful differences in patient outcomes when comparing clinicians with post-professional training to those without. The propensity score method proved to be a valuable way to account for differences at baseline between the groups. Conclusion Post-professional training does not appear to contribute to improved patient outcomes in the treatment of CLBP. This study demonstrates that propensity score analysis can be used to ensure that differences observed are true and not due to differences at baseline.
Species interactions and diversity: a unified framework using Hill numbers
William Godsoe
Rua Murray

William Godsoe

and 2 more

January 31, 2024
Biodiversity describes the variety of organisms on planet earth. Ecologists have long hoped for a synthesis between analyses of biodiversity and analyses of biotic interactions among species, such as predation, competition, and mutualism. However, it is often unclear how to connect details of these interactions with complex modern analyses of biodiversity. Using methods pioneered in studies of ecological-evolutionary dynamics, we link biotic interactions and changes in measures of biodiversity such as Hill numbers. We show that analyses of biodiversity obscure details about biotic interactions. For example, identical changes in biodiversity can arise from predation, competition or mutualism, locally or across a metacommunity. Our approach indicates that traditional models of community assembly miss key facets of diversity change. Instead, we suggest that analyses of diversity change should focus on partitions, which measure mechanisms that directly shape changes in diversity, notably relative fitness and immigration, rather than traditional analyses of biotic interactions.
A Systematic Review of the Epidemiology of Human Respiratory Viruses in Indonesia
Sankalpa Bhattarai
Hsien-Yao Chee

Sankalpa Bhattarai

and 4 more

January 31, 2024
Viral pathogens greatly contribute to higher respiratory disease burden among individuals living in low-to-middle income countries (LMICs). In Indonesia, influenza-like illness (ILI) and severe acute respiratory infection (SARI) surveillance networks have been established to better understand the epidemiology of viral respiratory disease; however, due to limited resources and operational capacity, data from these systems are sparse. Here, we summarize the results of a literature review conducted to identify published articles related to human respiratory viruses in Indonesia. We identified 66 scientific articles, published between 1998 and 2021. Of these, 21 (31.8%) studied influenza A or B, 17 (25.8%) studied influenza H5N1, 19 (28.8%) studied coronaviruses, 5 (7.6 %) studied RSV, and 2 (3.0 %) studied enterovirus. Our findings show that large numbers of studies in Indonesia were primarily conducted in response to viral respiratory disease outbreaks, but with limited epidemiological data. We also identified gaps in information regarding the geographical distribution of viral respiratory disease burden, as studies were more highly concentrated in populated cities, such as Jakarta, Java, and Bali. This review highlights the need for more robust surveillance of ILI and SARI cases throughout Indonesia, as well as allocation of more resources for viral respiratory disease etiology and epidemiological studies.
Physiological Control of Water Exchange in Anurans
Lee Lemenager
Christopher Tracy

Lee Lemenager

and 3 more

January 31, 2024
1. Research on water exchange in frogs has historically assumed that blood osmotic potential drives water exchange between a frog and its environment, but here we show that the “seat patch” (the primary site of water exchange in many anurans), or other sites of cutaneous water uptake, act as an anatomic “compartment” with a water potential controlled separately from water potential of the blood, and the water potential of that compartment can be the driver of water exchange between the animal and its environment. 2. We studied six frog species (Xenopus laevis, Rana pipiens, R. catesbeiana, Bufo boreas, Pseudacris cadaverina and P. regilla) differing in ecological relationships to environmental water. We inferred the water potentials of seat patches from water exchanges by frogs in sucrose solutions ranging in water potential from 0 to 1000 -kPa. 3. Terrestrial and arboreal species had seat patch water potentials that were more negative than the water potentials of more aquatic species, and their seat patch water potentials were similar to the water potential of their blood, but the water potentials of venters of the more aquatic species were different from (and less negative than) the water potentials of their blood. 4. These findings indicate that there are physiological mechanisms among frog species that can be used to control water potential at the sites of cutaneous water uptake, and that some frogs may be able to adjust the hydric conductance of their skin when they are absorbing water from very dilute solutions. 5. Largely unexplored mechanisms involving aquaporins are likely responsible for adjustments in hydric conductance, which in turn, allow control of water potential at sites of cutaneous water uptake among species differing in ecological habit and the observed disequilibrium between sites of cutaneous water uptake and blood water potential in more aquatic species.
Suspected adverse events following immunization against SARS-CoV2 in a university hos...
Dolores Rodriguez
Pilar Ordoñez

Dolores Rodriguez

and 10 more

January 31, 2024
Aim: Vaccination against SARS-CoV2 has been proposed as a fundamental element for the control of the pandemic. The aim of this study is to describe the suspected adverse reactions (ADRs) reported among vaccinated hospital workers. Methods: Descriptive study of suspected ADRs identified between January and March 2021. The suspected ADRs were identified by specifically designed electronic form and by spontaneous reporting. Data was also collected regarding the characteristics of the professionals, vaccine administered, severity, and outcome of the ADR. Results: 8,169 professionals received the two doses of SARS-CoV2 vaccine (6,672 Comirnaty® and 1,497 Spikevax®) and 894 reports of suspected ADR were reported (762 for Comirnaty® and 132 for Spikevax®), so a cumulative AEFIs incidence of 10.94% (95%CI: 10.27-11.62). The majority of ADRs were reported only after the second dose, 497(56.2%) while 211 (23.6%) was reported only after the first dose and a 186 (21%) after both doses. Symptoms were mostly mild, did not require medical assistance and disappeared in about 3 days. One hundred and seventeen professionals had a history of COVID-19. These reported, statistically significant, more suspected ADRs after the first dose (42.7%) than professionals with no history of COVID-19 (20.7%). Among the professionals, more ADRs occurred after the first dose with the Spikevax® vaccine (41.6%) than with the Comirnaty® vaccine (20.5%). Conclusion: The majority of the suspected ADRs reported were those described in the summary of product characteristics (SmPC). Professionals with history of COVID-19 reported more suspected ADRs after the first dose than professionals without history.
Hyoscine butylbromide associated psychosis: A case report
Durga Neupane
Nimesh Lageju

Durga Neupane

and 2 more

January 31, 2024
Abstract Hyoscine butyl bromide, an anti-spasmodic is often used for alleviation of colicky abdominal pain. Few studies have shown its safety and efficacy in children. Apart from common side effects, acute psychosis has been rarely reported. With this case report, we would like to reflect a message that hyoscine butylbromide should be used carefully in children, along with the emphasis on the correct dose, frequency and competency of the practicing clinician.
Protein Kinase D1 promotes the survival of Random-pattern Skin Flaps in Rats
Jianpeng Chen
Hongyu Chen

Jianpeng Chen

and 6 more

January 31, 2024
Background: Random-pattern skin flaps are often utilized to cover numerous skin defects that can occur for a variety of causes, although tissue ischemia is the most prevalent consequence that leads to surgery failure. Protein Kinase D1 (PKD1), a calcium/calmodulin-dependent serine/threonine kinase, has been linked to angiogenesis and has been shown to protect against ischemic cardiovascular disease in several studies. However, no relevant studies on skin flaps have been recorded. Methods: Sixty male Sprague-Dawley rats were randomly separated into control, PKD1, and CID755673 group. We observed postoperative survival, laser Doppler and lead oxide/gelatin angiography were used to assess blood flow, HE (hematoxylin and eosin) staining was used to observe neovascularization, and determined the level of related protein expression through Immunoblotting and immunohistochemistry. Results: The PKD1 group has the largest survival area and the most abundant blood supply. The level of angiogenesis and oxidative stress is the highest, and the level of apoptosis is the lowest. The CID755673 group is the opposite. Conclusion: The findings show that PKD1 increases the flap’s survival rate and is linked to increased angiogenesis, reduced oxidative stress, and apoptosis inhibition.
Face and content validity assessment of a novel post-thyroidectomy haematoma simulati...
Dora Amos
Issa Beegun

Dora Amos

and 2 more

January 31, 2024
Abstract Objectives The objective of this paper is to describe a novel post-thyroidectomy haematoma simulator and present data on its face and content validity and curriculum applicability. Methods A simple simulation model of a post-thyroidectomy haematoma was made using a C-spine collar, silicone sheets and thickened jelly. The model was worn by a simulated patient in a hybrid simulation. A prospective evaluation study was performed. Medical, nursing and theatre staff were recruited to complete a simulation using the model. All participants completed a 16-item questionnaire using a 5-point Likert scale to assess the following: face validity (FV), content validity (CV), task-specific validity (TV) and curriculum applicability. Non-parametric statistics were used. Results 74 participants completed the questionnaire. The model achieved median face validity of 4 (interquartile range (IQR): 4-5), median content validity of 4 (IQR: 4-5) and median task-specific validity of 5 (IQR: 4-5). In 14 out of 16 domains, participants gave a score of 4 or 5 (agreed or strongly agreed) more than 80% of the time. The median score for curriculum applicability was 5 (IQR: 4-5). Conclusions This home-made simulator for post-thyroidectomy haematoma evacuation achieved face and content validity. It is an accessible, cheap and potentially life-saving training tool. This model may be useful for multidisciplinary simulation-based training in the light of the recent DAS, BAETS and ENT UK consensus guidelines on managing post-thyroidectomy haematoma. Keywords: Simulation, post-thyroidectomy haematoma, hybrid simulation, face validity, content validity Key points: 1. Post-thyroidectomy haematoma is a rarely encountered and potentially fatal complication of thyroid surgery. 2. No simulation models for this condition have previously been validated. 3. We developed a simple, home-made, cost-effective hybrid simulation model. 4. The model was tested at three separate training events for ENT registrars and the multidisciplinary team. Data was collected using Likert-scale questionnaires. 5. The model achieved good face and content validity.
The Use of Extracorporeal Membrane Oxygenation as a Bridge to Bone Marrow Transplanta...
Marie Nader
Pramod Bonde

Marie Nader

and 4 more

January 31, 2024
An 18-year-old girl with high risk acute myeloid leukemia developed Streptococcus mitis septic shock and multi-organ dysfunction syndrome, including biventricular failure. Due to the anticipated reversibility of her cardiogenic shock, her young age and her favorable survival chance following allogeneic hematopoietic stem cell transplant, she was placed on full circulatory support with veno-arterial extracorporeal membrane oxygenation as a bridge to her successful HSCT two months later. This highlights the importance of prognostication in patient selection for extracorporeal life support. A multi-disciplinary approach is essential to each case until better initiation criteria, risk stratification and treatment protocols are established.
Echocardiographic diagnosis of a Case of High-output Heart Failure Caused by an Arter...
Yajuan Wei
huanhuan huo

Yajuan Wei

and 3 more

January 31, 2024
High-output heart failure is an important cause of heart failure that is associated with increased mortality, and most frequently caused by obesity, arteriovenous shunts, and liver disease. However, high-output HF caused by a neoplasm-related arteriovenous fistula in adults is uncommon. We report a case of high-output HF caused by massive arteriovenous fistula shunting associated with suspicious recurrent pelvic cellular leiomyoma. Echocardiography played an essential rale in identification of high-output HF and different etiologies of it by taking concern of stroke volume, cardiac output, cardiac index.
POMMS: Pre-Operative Misoprostol in Myomectomy Surgery: A Randomised Controlled Clini...
Lima Wetherell
Shamitha  Kathurusinghe

Lima Wetherell

and 7 more

January 31, 2024
Objective To assess the effect on intra-operative blood loss of using pre-operative sublingual misoprostol in abdominal and laparoscopic myomectomy surgeries compared to placebo. Design Double-blind placebo-controlled randomised study. Setting A single tertiary Gynaecology Unit in Melbourne, Australia. Population Women 18 years old undergoing laparoscopic or open myomectomy surgery. Methods Fifty three women undergoing laparoscopic or abdominal myomectomy surgery for symptomatic uterine leiomyomas were randomised to pre-operative sublingual 400mcg misoprostol (n=26) or placebo (n=27). Main Outcome Measures The primary outcome measure was intra-operative blood loss. Results There was no significant difference in intra-operative blood loss at myomectomy surgery between the misoprostol and placebo groups. Intraoperative blood loss in the misoprostol treatment group was 306ml +/- 281ml, compared to 325  352 ml in the placebo group; P=0.83. Both groups were adequately matched for baseline demographics and myoma size. Conclusions The study was not able to demonstrate that pre-operative sublingual misoprostol use at laparoscopic and abdominal myomectomy surgery resulted in a statistically significant reduction in intra-operative blood loss. This study provides a foundation for adequately powered trials assessing the effect of sublingual misoprostol on blood loss at myomectomy. Funding Funding was supplied via an Australia Gynaecological Endoscopy and Surgery Society (AGES) Research Grant. There were no conflicts of interest in this trial. Keywords Leiomyoma, myomectomy, misoprostol, blood loss, sublingual Tweetable abstract Pre-operative sublingual misoprostol may reduce intra-operative blood loss during myomectomy surgery but confirmation is required from a larger study.
Theoretical analysis of two collinear cracks subject to the quadratic thermo-magneto-...
Bing Wu
Daren Peng

Bing Wu

and 2 more

January 31, 2024
The problem of two collinear cracks subject to the quadratic thermo-magneto-electro-elastic loading is addressed in this paper. Taking advantage of the permeable crack models, the Fourier transform and superposition theorem, the exact solutions of physical quantities around two collinear cracks are obtained. It is shown that the effects of the dimensionless quantities between the upper and below crack-face (i.e., h_c ϵ_r and μ_r) on physical quantities of crack-face (i.e., Q_c, B_c , D_c , K_(ϕ^(*+))^Inn, K_(ϕ^(*+))^Out, K_(φ^(*+))^Inn and K_(φ^(*+))^Out)) in numerical results. It should be emphasized that because the theoretical solution obtained in this paper has an explicit form, it is convenient to solve the stress intensity factor. In particular, it is very convenient to solve the influence of various physical quantities on the stress intensity factor of the crack tip. It has more advantages than the numerical method.
Uniqueness results for the fourth order $p$-Laplacian equations of kirchhoff type wit...
Youyuan Yang
shaoyan zhang

Youyuan Yang

and 1 more

January 31, 2024
In this paper, by using the contraction mapping principle, we establish the existence and uniqueness of solutions for the fourth order $p$-Laplacian beam equations with Riemann-Stieltjes boundary conditions. Finally, some examples are presented to illustrate the main results.
Existence and uniqueness of weak solutions to the $n$-dimensional magneto-micropolar...
Liangliang Ma

Liangliang Ma

January 31, 2024
The aim of this paper is to study the Cauchy problem for the $n$-dimensional magneto-micropolar equations with fractional dissipation. By some subtle estimates, Littlewood-Paley theory and compact method, we prove the local existence and uniqueness of the system in inhomogeneous Besov spaces under various fractional dissipation assumptions. Explicitly, we examine the existence and uniqueness of weak solutions to the $n$-dimensional $(n\geq2)$ magneto-micropolar equations with fractional dissipation $(-\Delta)^\alpha$, fractional magnetic diffusion $(-\Delta)^\beta$ and fractional spin viscosity $(-\Delta)^\gamma$, and the aim is at the uniqueness of weak solutions in the weakest possible inhomogeneous Besov spaces. We establish the local existence and uniqueness in the functional settings: i) $u_0\in{\mathcal{B}}^{1+\frac{n}{2}-2\alpha}_{2,1}(\mathbb{R}^n),\ b_0\in{\mathcal{B}}^{\frac{n}{2}}_{2,1}(\mathbb{R}^n),\ w_0\in{\mathcal{B}}^{1+\frac{n}{2}-2\gamma}_{2,1}(\mathbb{R}^n)$ with one of the following situations: $n=2,\ \alpha=1,\ \beta=0,\ \frac{1}{2}\leq\gamma<1$; $n=3,\ \alpha=1,\ \beta=0,\ \frac{1}{2}\leq\gamma<\frac{3}{2}$; $n>3,\ \alpha=1,\ \beta=0,\ \frac{1}{2}\leq\gamma<\frac{n}{2}$; $n\geq2,\ \frac{1}{2}\leq\alpha<\frac{n}{2},\ \beta\geq0,\ \alpha+\beta\geq1,\ 1\leq\gamma<\frac{n}{2}$; ii) $u_0\in{\mathcal{B}}^{1+\frac{n}{2}-2\alpha}_{2,1}(\mathbb{R}^n),\ b_0\in{\mathcal{B}}^{\frac{n}{2}}_{2,1}(\mathbb{R}^n),\ w_0\in{\mathcal{B}}^{\frac{n}{2}}_{2,1}(\mathbb{R}^n)$ with $1\leq\alpha<\frac{n}{2}$, $\beta\geq0$ and $0\leq\gamma<\frac{n}{2}$, $n\geq2$, in which we show the magneto-micropolar equations admit a unique weak solution. These results in this paper improve the known results and help us to understand more deeply the role of fractional Laplace operator in the study of hydrodynamic equations.
FIXED POINTS OF WEAKLY K-NONEXPANSIVE MAPPINGS AND A STABILITY RESULT FOR FIXED POINT...
SAYANTAN PANJA
Kushal Roy

SAYANTAN PANJA

and 4 more

January 31, 2024
In this article, we introduce a new type of non-expansive mapping, namely weakly K-nonexpansive mapping, which is weaker than non-expansiveness and stronger than quasi-nonexpansiveness and prove some weak and strong convergence results, using weakly K-nonexpansive mappings. Also we define weakly (α;K)-nonexpansive mapping and using it prove one stability result for JF-iteration process. Some prominant examples are presented which illustrats the facts. A numerical example is presented to compare the convergence behavior of some known iterative algorithms, for weakly K-nonexpansive mappings. Moreover we show by an example that the class of α-nonexpansive mappings due to Aoyama and Kohsaka and the class of generalized α-nonexpansive mappings due to Pant and Shukla are independent. Finally, our fixed point theorem is applied to obtain solution of a nonlinear fractional differential equation.
miR-144-3p is a biomarker related to severe corticosteroid-dependent asthma.
Jose  Rodrigo-Muñoz
Marta Gil-Martinez

Jose Rodrigo-Muñoz

and 7 more

January 31, 2024
Background MicroRNAs are noncoding molecules that act both as regulators of the epigenetic landscape and as biomarkers for diseases, including asthma. In the era of personalized medicine there is a need for novel disease-associated biomarkers that can help in classifying diseases into phenotypes for treatment selection. Currently, severe eosinophilic asthma is one of the most widely studied phenotypes in clinical practice, as many patients require higher and higher doses of corticosteroids, which in some cases fail to achieve the desired outcome. Such patients may only be benefit from alternative drugs such as biologics, for which novel biomarkers are necessary. Methods MiR-144-3p was evaluated in airway biopsies and serum from asthmatics and healthy individuals. mRNA was studied in asthmatic biopsies and smooth muscle cells transfected with miR-144-3p mimic. In silico regulation of miR-144-3p was performed using miRSystem, miRDB, STRING and ShinyGO for pathway analysis. Results We found that miR-144-3p is a biomarker associated to asthma severity and corticosteroid treatment. MiR-144-3p is increased in asthmatic lungs and its presence correlates directly with blood eosinophilia and with the expression of genes involved in asthma pathophysiology in the airways. When studied in serum, this miRNA was increased in the severe asthmatics and associated with higher doses of corticosteroids, thereby making it a potential biomarker for severe asthma previously treated with higher doses of corticosteroids. Conclusion MiR-144-3p is associated with severe disease in both the airways and serum of asthmatics, and this association is related to corticosteroids treatment.
Perceptions, healthcare messaging and its impact on COVID vaccine uptake in pregnancy...
Sonika Sethi
Amy Thompson

Sonika Sethi

and 7 more

January 31, 2024
Objective: To gain in-depth insights into factors affecting COVID-19 vaccine acceptance in pregnant women. This demographic has lower rates of COVID vaccination despite being disproportionally negatively affected by COVID. Design: A single centre cross-sectional online survey distributed 13th August 2021 to 21st September 2021 on local networks. Setting: Online Population: Pregnant population in a large District General Hospital in the West Midlands, UK. Main Outcome Measures: i) demographic and baseline data ii) awareness of information sources; iii) opinions on COVID and vaccination, iv) vaccination decisions. Results: 92 total eligible responses were quantitatively and qualitatively analysed. 60.9% (n=56) had declined, or would decline, a COVID-19 vaccination. Those who had a previous negative pregnancy experience were significantly more likely to accept a COVID-19 vaccination (OR 3.9; p<0.05, 95% CI 1.32-11.52). Over half (53.2%) of participants either agreed or strongly agreed that discussion with a healthcare professional was important in decision making on vaccination . GPs were the least supportive of the vaccination (62.5%) compared to midwives (78.8%) and obstetric consultants (81.8%). The most common reason for declining the vaccine were perceived risks to the fetus; this was also frequently reported in the qualitative analysis. Other qualitative themes included; distrust of recommendations, conflict of information and uncertainty. Conclusions: There is a need for consistent health professional messaging around vaccine uptake in pregnancy and the use of appropriate evidence based information, particularly focusing on its safety and impact on fetus. There is a need to nurture a collaborative approach and informed decision making.
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