Primary cutaneous anaplastic large cell lymphoma (PC‐ALCL) is a CD30+ lymphoproliferative disorder of the skin. There are currently no case reports involving the presentation of Agent Orange-induced PC-ALCL of the hand, surgical excision, and follow-up treatment. We present a case of Agent Orange-induced PC-ALCL and the subsequent surgical management.

Immunotherapy using Histobulin was attempted in four cases of atopic dermatitis. The patients improved considerably, and one patient showed remission. The patients showed considerable improvement with a lower frequency of upper respiratory infections during immunotherapy.

This is the first report of marked improvement of oral intake by third-line nivolumab monotherapy in a gastric cancer patient with insufficient oral intake and European Cooperative Oncology Group performance status 2. We should consider immune checkpoint inhibitors for microsatellite instability-high gastric cancer, regardless of the patient's general condition.

We report a case of perforation of the superior vena cava caused by a multi-lumen central venous catheter. Diagnosis was delayed because extra-corporeal blood flow was not interrupted. Clinicians should be aware of potential vascular complications associated with multi-lumen catheters even in cases in which hemodialysis continues with no complications.

We present a patient with myocardial infarction and cardiogenic shock who underwent high-risk percutaneous coronary intervention with Impella support, and developed iliac artery thrombosis at the Impella access site. Percutaneous thrombectomy was accomplished using the FlowTriever system, highlighting this approach as a potentially safe and effective alternative to surgery.

4 cases have been reported from a tertiary referral hospital in Tehran, of which 3 have confirmed COVID-19 infection and one has been highly suspicious. The cases describe different cardiovascular presentations that can be linked to COVID-19 infection, including myocardial infarction, in-stent restenosis, myopericarditis and tamponade, and aortic dissection.

Sarcomas are a rare but aggressive type of malignancy that are often diagnosed late. This case describes an atypical presentation of sarcoma manifesting as abdominal pain, which previously has not been found in literature. We highlight the importance of pursuing additional workup when clinical suspicion for malignancy arises.

Rupture of pulmonary artery pseudoaneurysm (PAP) can result in life-threatening hemoptysis. A 65-year-old male was diagnosed with PAP based on chest contrasted computer tomography (CT). He coughed up massive amounts of blood and could not be resuscitated. In the autopsy, macroscopic and microscopic findings supported the clinical course.

Hemophagocytic syndrome have experienced a very significant revival in recent years, we report a rare case of secondary HLH to Hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection. In addition to the treatment for hepatitis the patient underwent therapy for HLH, with this treatment we obtained complete remission.

A 39 year old patient was presented with bacterial meningitis after having endoscopic surgery for removal of a benign pituitary tumor. Cerebrospinal cytology showed a marked hemophagocytic activity.

Clinical Image

We suggest PLAID,APLAID and FCAS3 have to be considered as same diseases,because of our long-term clinical experiences and genetic results in six patients.Small proportion of CVID patients are also PLAID/APLAID/FCAS3 patients and all these have disease-causing-mutations in PLCG2-genes,so it may be better to define all of them as “PLCG2 deficiency”.

COVID-19 causes significant hypoxia along with an inflammatory milieu, which may lead to secondary myocardial infarction and also atherosclerotic plaque rupture. Here we present a case of COVID-19 presented with ACS followed by PTE and CVA.

A 74-year-old female with cervical cancer post radical hysterectomy developed bilateral ureter stricture with pyonephrosis. Retrograde ureteric stent was performed and it was considered an effective procedure other than percutaneous nehrostomy and nephrectomy.

This is a report of an 8-year-old male with Schwartz-Jampel syndrome with severe obstructive sleep apnea. Dental findings include severe maxillary crowding, posterior crossbite, missing lower incisors, and supernumerary lower premolar. Significant craniofacial characteristics include Type I skeletal relationship with bimaxillary hypoplasia, hyperdivergent skeletal pattern, severe constriction of dental arches.

Pneumopericardium, or gas in the pericardial sac, is a rare condition that typically presents with chest pain or pericarditis, but can be severe enough to cause tamponade physiology. The images presented show the typical appearance of pneumopericardium. This patient had tamponade physiology requiring a pericardial drain in the operating room.

Bing-Neel syndrome (BNS) remains a rare complication of Waldenstrom Macroglobulinemia. Given the paucity of this disease, treatment guidelines are based on small clinical trials with limited participants. Here we present a case of BNS that developed while on ibrutinib therapy, followed by a review of the next steps in management.

During coronavirus disease 2019 (COVID-19) pandemic, coinfections with other viral infections are not uncommon, but concomitant atypical bacteria are rare. Herein, we describe a young female COVID-19 patient who developed acute cold agglutinin disease secondary to Mycoplasma pneumoniae. Using an azithromycin-containing COVID-19 therapeutic regimen, both pneumonia and anemia resolved uneventfully.