From Childhood Icterus to Adolescent Gallstones: Clinically Diagnosed Crigler-Najjar Syndrome Type IIDanish Kumar GoswamiEmail: daniahgoswami34@gmail.com Institute/Affiliation: Department of Internal Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.ORCID: 0009-0007-6209-4048Barkha Goswami Email: barkhagoswami9900@gmail.com Institute/Affiliation: Department of Internal Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.ORCID: 0009-0005-3435-6237Samiullah ShaikhEmail: sami.shaikh581@gmail.comInstitute/Affiliation : Department of Internal Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, PakistanORCID: 0009-0008-8237-9080Abdul Ghani RahimoonEmail: ghani_2006a@hotmail.com Institute/Affiliation: Department of Internal Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.ORCID: 0009-0003-5256-393XRakesh Soni Email: rssoni9999@gmail.com Institute/Affiliation: Department of Internal Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.ORCID: 0009-0000-0253-1137Kamil Ahmad Kamil (Corresponding Author)Email: drkamilahmad1@gmail.comContact: +93 70473 6171Institute/Affiliation : Mirwais Regional hospital, Kandahar, AfghanistanKeywords: Unconjugated Hyperbilirubinemia, Crigler-Najjar Syndrome, Jaundice, Cholelithiasis, Gastroenterology/Hepatology, General Medicine, and Genetics.Key Clinical Message: This case highlights an uncommon adult presentation of Crigler-Najjar Syndrome Type II, complicated by cholelithiasis, underscoring the need to consider inherited disorders of bilirubin metabolism in persistent unconjugated hyperbilirubinemia. Recognizing phenobarbital responsiveness remains crucial for diagnosis in resource-limited settings where genetic testing is not readily available.