We described the clinical, biochemical, hormonal and developmental status of a patient with 49,XXXXY syndrome with routine Fraccaro syndrome features accompanied with sexual masturbation behavior. This study were compiled and summarized the clinical features and also maternal age at birth time in all yet 49,XXXXY reported in the Iranian population.

Acalvaria is a rare and lethal congenital malformation characterized by the absence of the cranial vault bones, dura mater and associated muscles with complete cranial content. We report a 5-year-old Malian girl seen at 20 months old for facial dysmorphia, hemiparesis, and a cranial bone defect that improved progressively.

Chylous ascites following trauma in children is very rare, and to the best of our knowledge, there are very few reports in this regard. Here, we report a 7-year-old girl who was referred to our center with CA after a car accident.

An 80-year old gentleman with very severe aplastic anemia was treated with standard combination therapy of equine antithymocyte globulin and cyclosporine A. His death shortly after treatment could be attributed to his advanced age, severe pancytopenia at diagnosis, absence of minor paroxysmal nocturnal hemoglobinuria clone and immunosuppressive therapy-related complications.

The objective of this case series is to describe the diagnosis, therapeutic intervention, and outcome of pit viper envenomation in five pediatric dogs. All five puppies survived to discharge, with no known complications from their envenomation or antivenom administration.

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder with tumor predisposition in the parathyroid gland, anterior hypophysis and pancreatic islet cells. Here we describe the first Costa Rican MEN1 case with a novel MEN1 mutation in a 37-year-old male with history of nephrolithiasis and recurrent hypoglycemia

A total of 89 children had their urinary catheters removed 4 weeks after the operation.The children, diagnosed with urine leakage, were successfully repaired after the leakage occurred one year later at one time.The one-time success rate of this operation was 87.6% and the incidence of the urethral fistula was 12.6%

A 72-year-old female used the oral phosphate binder lanthanum carbonate for 6 years, before discontinuing it after receiving a pancreas and kidney transplant. Now, 7 years after discontinuation, the patient developed bilious emesis. An upper gastrointestinal endoscopy showed an unspecific gastritis. Biopsies showed subepithelial crystalline deposits consistent with gastric lanthanosis.

A 59-year-old man with a long smoking history presented with sudden back pain. Frank's sign was noticed in his bilateral ears, and computed tomography revealed Stanford type A acute aortic dissection. If young patients have Frank's sign, attention should be paid to atherosclerotic disease including aortic disease.

Arteria lusoria is a rare vascular malformation. It remains a rare cause of dysphagia which should be considered in the face of any dysphagia unexplained by the usual endoscopic and radiological investigations.

Coronavirus-2019 (COVID-19) pandemic is a global health challenge where pregnant women are potentially more vulnerable to respiratory infections. We describe the successful management of a case a 35 years old pregnant woman, G3, P1, with a history of caesarian section who tested positive for COVID-19 and required critical care support

Confluent and reticulated papillomatosis (CRP) is a rare skin condition of uncertain etiology. The anti-bacterial and most importantly the anti-inflammatory mechanisms of some antibiotics seem to explain the effectiveness of these medications. Other measures such as reducing weight and treating an underlying endocrine disorder may be helpful.

Foot and ankle TB is rarest form of skeletal TB. It's symptoms may present slowly over an extended period of time, making a diagnosis difficult. For the best outcome and to reduce the risk of deformity diagnosis must be early. The treatment is 12 months rifampin-based regimen for drug-susceptible TB.

IntroductionVasculitis is an inflammatory disease with variable end-organ damage that is classified based on involvement of small, medium or large vessels.1 Leukocytoclastic vasculitis is a small-vessel vasculitis predominantly affecting dermal capillaries and venules, and often secondary to underlying systemic vasculitis, infection or drug exposure.1 Commonly implicated drugs include beta-lactam antibiotics and non-steroidal anti-inflammatory drugs,1 while calcium channel blockers and hydroxymethylglutaryl-coA reductase inhibitors (statins) have been rarely associated2-6 – with no previous formal case report for verapamil. We present a case of cutaneous leukocytoclastic vasculitis associated with recently initiated verapamil and atorvastatin.

Consider amiodarone pneumonitis as an important differential diagnosis of ARDS , especially In clinically ill patients with renal failure who recently received Intravenous amiodarone .

Introduction: Rapidly progressive glomerulonephritis is a very rare and atypical form of renal syphilis. Case presentation: 50 year old lady presented facial swelling, hematuria, and elevated creatinine. Both RPR and TPHA was reactive. Treatment with weekly benzathine penicillin resulted in dramatic response. Conclusion: consider syphilis as reversible cause of RPGN.

Objective: To describe the outcome following limb-sparing subtotal hemipelvectomy (iliectomy) in a dog with ilial chondrosarcoma. Animal: A 9.5-year-old female spayed Boxer with grade 2 chondrosarcoma of the ilium Study Design: Case report.

This clinical case is showing a potential synergistic neuroprotective interaction of Cerebrolysin and high doses of aspirin. The case describes the significant recovery of neurological deficits in a patient with moderate ischemic stroke caused by right posterior cerebral artery thrombosis after treatment with Cerebrolysin in combination with aspirin