IntroductionPartial unilateral lentiginosis (PUL) is a rare benign pigmentary disorder where multiple lentigines are typically found clustered together within an area of normal skin.1 The lesions are confined to one or more dermatomes in a segmental pattern with a sharp demarcation at the midline.2,3 In most patients, the lesions first appear or are often noticed during early childhood.4 It can occur anywhere on the body, including face, neck, trunk and extremities.3 It is believed to be occurred due to somatic mosaicism of several “developmental” pigmentary genes confined to neural crest melanoblast.5,6 Due to its similarity with nevus spilus macules and other pigmentary disorders it needs to be carefully diagnosed with proper history, dermatological examination and histopathological evaluation.6 Although treatment is not necessary, people tend to seek consultation due to cosmetic reasons.7 There is no established standard treatment for PUL. However available Treatment modalities includes laser therapy, topical agents such as tretinoin, hydroquinone.8 This case report has been reported in line with CARE guidelines.9

Management of Impacted Central Incisors Due to MesiodensDr Hananeh PourheidaryDepartment of Periodontology, Shahed UniversityCorresponding author: Dr. Hananeh Porheidary, Email:hpourheidary@gmail.com

Conservative Management of Atrioventricular Groove Hematoma in Mitral Valve Repair Surgery: A Case ReportFirst author’s given name : Xia; Family name: Zhang.Author’s names (given name, family name) : Xia Zhang1 ; Yangzhao Zhou1 ; Zhaoshun Yuan1 ; Jianming Li1 ; Kang Zhou1* .

A Case Report on Disseminated Mycobacterium Avium Complex Infection in an Otherwise Healthy Individual - A Diagnostic Challenge

A document by Ali Chamani. Click on the document to view its contents.

Metastatic Cutaneous Abscesses as Initial Presentation of Tuberculosis in an Immunocompetent PatientReshma Modi BS1, Garrett Chan MD2, Alexander Garcia DO21Cooper Medical School of Rowan University, Camden, NJ, USA2Department of Internal Medicine, Cooper University Hospital, Camden, NJ, USAKey words: tuberculosis; disseminated tuberculosis; cutaneous abscess; extrapulmonary tuberculosis

A document by Rajabu Athumani Bakari. Click on the document to view its contents.

Blinatumomab along with Combined Antifungal Agents for Refractory adult acute lymphoblastic leukemia with invasive aspergillosis: a case report

A document by Rafael Castellanos - Bueno . Click on the document to view its contents.

IntroductionImmune checkpoint inhibitors (ICIs) are approved for the management of solid and hematologic malignancies and have significantly improved cancer-related care. ICIs augment the intrinsic immunity through various mechanisms including targeting programmed cell death protein 1 (PD-1), cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), and ligand proteins on tumor cells. The combined effects of ICIs block the inhibition of T-cells and allow them to kill cancer cells. Although significant antitumor efficacy has been reported, a wide range of life-threatening inflammatory and autoimmune side effects have been associated with ICIs [1].ICI-induced myocarditis with myositis/myasthenia gravis overlap syndrome is a rare adverse effect of ICI therapy and carries a high mortality [2]. Antibodies are used in diagnostics and the disease is known to confer pathogenicity through certain molecular targets: acetylcholine receptor antibody [3], muscle-specific receptor tyrosine kinase [4], and numerous extracellular and intracellular antibodies [5]. However, 10-15% of patients with ICI-induced myasthenia gravis may be seronegative and antibody detection has proven invaluable in measuring disease severity in patients with myasthenia gravis [6]. Ultimately, the diagnosis is clinical while novel antigenic targets and their diagnostic relevance continues to be studied. We present two cases of ICI-induced myocarditis with myositis/myasthenia gravis overlap syndrome and review current literature to emphasize its severity and management.

A document by saeed asgary. Click on the document to view its contents.

Title: Hemorrhagic Pericardial Effusion and Gastrointestinal Bleed After Atrial Fibrillation Epicardial Ablation: A Case ReportAuthor:Kairui Sun, DO, Michigan State University College of Osteopathic MedicineCorresponding Author:Kairui Sun965 Wilson Rd.East Lansing, MI 48824Email: sunkairu@msu.eduPhone: (517)402-0673Fax: (517) 432-2125Keywords: Hemorrhagic pericardial effusion, gastrointestinal bleeding, atrial fibrillation, epicardial ablation, case report

A document by Rajabu Athumani Bakari. Click on the document to view its contents.

A document by Rohit Pandit. Click on the document to view its contents.

A case of acute disseminated encephalomyelitis in an infant with mild paralysisHideki Tanouea, MD, Sayaka Ishiharaa, MD, Mari Asakuraa, MD,Masahiro Nodaa, MD, PhD, Kunihiro Obaa, MD, PhD, Masashi Ogasawaraa, MD, PhD

Acute renal dysfunction and candidemia due to bilateral ureteral obstruction by Candida albicans fungus balls – Case reportMizuki Kasahara*, Fumito Yamabe, Masato Uetani, Hideyuki Kobayashi, Koichi Nakajima, Yozo MitsuiDepartment of Urology, Toho University Faculty of Medicine, 143-8540 Tokyo, Japan

not-yet-known not-yet-known not-yet-known unknown 1 Introduction Tuberculosis (TB) remains a major global infectious disease burden, classified into pulmonary and extrapulmonary forms. Extrapulmonary TB (EPTB), which affects organs outside the lungs, is relatively uncommon in Taiwan, comprising only 5.5% of new TB cases in 2023[1]. The most frequently involved sites are lymph nodes and bones/joints; however, gastrointestinal tuberculosis (GITB) accounted for approximately only 10% of EPTB[1]. GITB predominantly affects the ileocecal region, while upper gastrointestinal involvement is rare[2]. Diagnosis is often delayed due to nonspecific symptoms and low bacterial load[3]. EUS-FNB offers a minimally invasive and effective modality to obtain tissue for diagnosis from deep-seated abdominal lesions[4]. It is crucial to improve outcomes with immediate tissue acquisition and accurate diagnosis, followed by standard anti-TB therapy.

A document by Nishan Uprety. Click on the document to view its contents.