In resource-constrained settings, mucopolysaccharidosis (MPS) is a rare hereditary metabolic illness that frequently remains undiagnosed. We present a scenario that illustrates the challenges in diagnosing and managing MPS due to test inaccessibility, as well as potential approaches to minimize the hurdles.

We report a patient that underwent a redo complex AVR. In the context of severe AR and dilated LV, we experienced that it is safer to start the LV venting after aortic cross clamping. NIRS in this setting can be a useful tool to prevent potential severe neurological damage.

The objective of this case report was to describe the treatment sequence of an immediate dental autotransplantation, with the use of technology such as the elaboration of a 3D replica made on a computer in conjunction with cone beam computerized tomography and the use of an piezoelectric

A descriptive retrospective review of two Danish families with Axenfeld-Rieger Syndrome. Documenting clinical findings, treatment of the dental anomalies and dentofacial deformities is described. This article demonstrates the importance of early diagnosis, referral and treatment in highly specialized center to receive the best outcome.

Middle ear Neuroendocrine adenomas are rare tumors that can be easily confused as glomus tympanicum of the middle ear. 33-year-old man with no comorbidities who presented with complaints of right ear foreign body sensation and was later diagnosed as a neuroendocrine adenoma of the middle ear.

We report the case of a 42 years old young patient who was examined in the emergency department for epigastric pain lasting for 3 days. The abdominal tomodensitometry allowed to highlight the presence of an intra peritoneal effusion without pneumopertoneum. The patient underwent an exploratory laparoscopy. There was peritoneal toilet

Amiodarone is commonly used in acute care due to its effectiveness in several arrythmias and safety if structural heart disease is present or unknown. However, it can have a proarrhythmic effect. We presented a case of iatrogenic arrhythmic storm due to concomitant use of amiodarone plus tiapride resolved with isoproterenol.

Primitive neuroectodermal tumor (PNET) is a highly aggressive tumor and mostly develops in children and young adults. PNETs of peripheral nerves are uncommon. Ulnar nerve, in particular, is an extremely peculiar origin for PNET and to the best of our knowledge only few well-documented cases have been yet reported.

In this case study, we report an 11-year-old male patient who had jaundice, hepatosplenomegaly, and chronic mild congenital non-autoimmune hemolytic anemia. In our patient, a novel homozygous missense mutation in the PIEZO1 gene was detected using a gene-targeted Next-Generation Sequencing panel: c.3364G>A (p.Glu1122Lys), confirming the diagnosis of DHS.

We enrolled a patient diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN) . We have found that TET2, KRAS and BRAF may be involved in the development of the disease, and the combination therapy of Decitabine (DAC) and Arsenic acid (ASO) may be effective for BPDCN harboring the TET2 mutations.

Giant Tumor of the perineal regionKey clinical message: Giant condyloma acuminatum, also known as, Buschke-Lowenstein tumour is a very rare, sexually transmitted disease. It is a slow-growing, destructive lesion that affects the anogenital region. The HPV has been identified as an important contributory factor in the development of this tumor.Key words: Dermatology, oncology, Giant condyloma acuminatum , HPV.A 48-year old man presented with a giant lesion of the perineal region which appeared 10 years before and gradually increased in size. Clinical examination revealed a lobulated, exophytic, non-painful, non-bleeding, cauliflower-shaped lesion on the penis and the scrotum, measuring approximately 8 x 7 cm suggestive of a giant condyloma acuminatum (Figure 1). There were no enlarged inguinal nodes. Magnetic resonance imaging of the pelvis and the abdomen revealed no regional lymph node involvement or evidence of distant metastasis. A skin biopsy confirmed the diagnosis of papillary condyloma acuminatum secondary to human papillomavirus (HPV). Radical excision of the entire lesion showed no signs of invasion. Blood tests for detecting Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), Hepatitis C virus (HCV) and syphilis were negative. Giant condyloma acuminatum, also known as, Buschke-Lowenstein tumour is a very rare, sexually transmitted disease.1,2 It is a slow-growing, expansive, cauliflower-like, destructive lesion that affects the anogenital region.1,2 The HPV has been identified as an important contributory factor in the development of this tumor.1,2

Unusual tumor of the toeKey clinical message: Giant Cell Tumor is a soft-tissue tumor that has a very low potential for malignant change. Involvement of the phalanges of foot is very rare and only a few cases have been reported.Key words: Dermatology, oncology, Giant cell tumor, bone tumors.A 39-year-old woman presented with complaints of pain and swelling of the left second toe for four months. The mass had been slowly increasing in size over the previous 3 years. On examination, there was diffuse swelling of the left second toe with erythematous and shiny overlying skin (Figure 1). The X-ray showed an osteolytic expansive lesion with cortical destruction in the region of the distal phalanx of the second toe. No calcification or periosteal reaction was observed. Magnetic resonance (MR) images showed a mass measuring 1×1.5 cm that was heterogeneously hypo intense on both T1- and T2-weighted MR images. This mass showed a marked, diffuse and heterogeneous enhancement on the contrast T1- weighted image. Surgical excision of the tumor was performed. Histopathological examination confirmed the diagnosis of Giant Cell Tumor (GCT) (Figure 2). The patient’s postoperative course was uneventful, and no recurrence or metastasis was observed. GCTs are soft-tissue tumors that have a very low potential for malignant change. It account for approximately 6% of all bone tumors.1,2 It typically involves the long bones in young adults. 1,2 Involvement of the phalanges of foot is very rare and only a few cases have been reported.1,2

COVID 19 is associated with pulmonary cavitation as rare late complication . Cavitatory lesion in COVID 19 recovered patient is very rare and can cause significant morbidity and mortality. we present case series associated with pulmonary cavitation as late complication.

An elderly female with multiple comorbidities presented with acute onset of severe urinary retention immediately following placement of an intrathecal morphine pain pump. This case highlights the need to closely monitor chronic pain patients with complex medical histories who may be uniquely predisposed to opioid-mediated severe urinary retention.

A 68-year-old female was operated for a giant dedifferentiated retroperitoneal liposarcoma (RLS) encasing entirely the right kidney. She had an en-bloc resection of the tumor with right nephrectomy. The en-bloc resection should avoid R1 resection margins. Renal conservation is suggested if the kidney is widely displaced and for elderly patient.

Uremic stomatitis is a rare manifestation associated with longstanding uremia in chronic renal failure patients. Its evolution is favorable with earlier institution of renal replacement therapy. This case shows that this condition should always be suspected by the dentist when the context of advanced renal disease is present.

The treatment effect of trigeminal postherpetic neuralgia is often unsatisfactory. We describe a case of low temperature plasma technique combined with lateral injection of trigeminal ganglion in the treatment of senile trigeminal postherpetic neuralgia.

A 82 years old female presented with cellulitis with abscess of the left foot after 10 days. We are reporting a case report of complex wound healing with upto 70% skin loss over dorsum of foot with the application of Negative Pressure Wound Therapy and dressing with placental extract gel.