There has been a significant increase in unexpected deaths due to major adverse cardiocerebrovascular events (MACCE) in the post-COVID-19 era. How to effectively control and prevent these events and adverse clinical outcomes is a vital topic in the globe. Since the innovative “magic polypill” or E(e)SEEDi plays a crucial role in human health and longevity, it just likes a “super-vaccine” due to improvement of immunity and prevention of cardiovascular diseases (acute myocardial infarction, venous thrombosis, stroke and sudden cardiac death), as well as diabetes and cancer. Additionally, it can benefit the health of individuals who are more prone to have unhealthy lifestyle. The interconnected nature of these factors, as explained by game theory, may contribute to the increased risk of MACCE and understanding related macro-mechanisms. In conclusions, as a “super-vaccine” with crucial effects on blood and vascular health, the E(e)SEEDi helps prevent MACCE among individuals, particular young and middle-aged those.