Figure 2 Possible macro-mechanisms of the “magic polypill” or E(e)SEEDi.
A change in one element will affect the other four elements, while also being influenced by the other four elements. Here, E: external environment; e: internal environment; S: sleep; Em: emotion; Ex: exercise; D: diet; hs: healthy status; E.as: abnormal status of external environment; e.as: abnormal status of internal environment; S.as: abnormal status of sleep; Em.as: abnormal status of emotion; Ex.as: abnormal status of exercise; D.as: abnormal status of diet; DS: dying status.
For example, insufficient Yang Qi in the internal environment of the human body can be regulated and improved through the external environment, sleep, emotion, exercise, and diet. A study showed that the levels of free testosterone and sex hormone-binding globulin are associated with high risk for incident cardiovascular events (such as AMI, stroke, and SCD) in middle-aged men.38 Herein, people should keep enough physical activity and rational diets so as to enhance the levels of these biomarkers. Another example, if individuals have sleep disorders or insomnia, they should improve their internal and external environment, emotion, exercise, and dietary regulation. A recent study indicated that individuals with persistent physical activity have better sleep quality than those inactivity.39 This means that exercise may treat insomnia and counter poor sleep quality. If subjects have depression or anxiety related to negative emotions, they may regulate and cure these symptoms by improving their internal and external environment, sleep, exercise, and diet.
In addition, there is a typical example that can explain the interrelated effects of the “HE 5”. A “vegetative person”, which can be understood as a “super-sleeper”, with almost zero reactions in terms of internal and external environment, emotion, exercise, and autonomous diet. Herein, subjects’ sleep aspect rises to the extreme, actually, seems a state of “long-term sleep”. Therefore, people can easily understand these macro-mechanisms of the “magic polypill” or E(e)SEEDi and its effects on human health. Actually, there is often a phenomenon of “one thing falling one thing” in nature. For example, a study found that heat shock protein 47 links to immobility-associated protection of venous thromboembolism in cross-species.40 This can also be described as the “Nash equilibrium”.
In fact, currently, all surgical treatments can be understood as “improvement of human internal environment”, and all agent treatments can be understood as “generalized dietary therapy”, since any drug is also a “generalized food” for intake to treat human diseases. As we know, traditional Chinese medicine has the concept of “medicine and food having the same origin”. Herein, the “magic polypill” or E(e)SEEDi is indeed a “super-vaccine” and a “super-therapy”. And it should be positively conducted in current clinical practice (Table 1). For example, we may adjust self-emotions through behaviours and activities of our main organs “brain-ears-eyes-foots-hands-legs-mouth-nose” for major mental disease including anxiety and depression (Table 2).