Figure 2 Possible macro-mechanisms of the “magic polypill” or
E(e)SEEDi.
A change in one element will affect the other four elements, while also
being influenced by the other four elements. Here, E: external
environment; e: internal environment; S: sleep; Em: emotion; Ex:
exercise; D: diet; hs: healthy status; E.as: abnormal status of external
environment; e.as: abnormal status of internal environment; S.as:
abnormal status of sleep; Em.as: abnormal status of emotion; Ex.as:
abnormal status of exercise; D.as: abnormal status of diet; DS: dying
status.
For example, insufficient Yang Qi in the internal environment of the
human body can be regulated and improved through the external
environment, sleep, emotion, exercise, and diet. A study showed that the
levels of free testosterone and sex hormone-binding globulin are
associated with high risk for incident cardiovascular events (such as
AMI, stroke, and SCD) in middle-aged men.38 Herein,
people should keep enough physical activity and rational diets so as to
enhance the levels of these biomarkers. Another example, if individuals
have sleep disorders or insomnia, they should improve their internal and
external environment, emotion, exercise, and dietary regulation. A
recent study indicated that individuals with persistent physical
activity have better sleep quality than those
inactivity.39 This means that exercise may treat
insomnia and counter poor sleep quality. If subjects have depression or
anxiety related to negative emotions, they may regulate and cure these
symptoms by improving their internal and external environment, sleep,
exercise, and diet.
In addition, there is a typical example that can explain the
interrelated effects of the “HE 5”. A “vegetative person”, which can
be understood as a “super-sleeper”, with almost zero reactions in
terms of internal and external environment, emotion, exercise, and
autonomous diet. Herein, subjects’ sleep aspect rises to the extreme,
actually, seems a state of “long-term sleep”. Therefore, people can
easily understand these macro-mechanisms of the “magic polypill” or
E(e)SEEDi and its effects on human health. Actually, there is often a
phenomenon of “one thing falling one thing” in nature. For example, a
study found that heat shock protein 47 links to immobility-associated
protection of venous thromboembolism in
cross-species.40 This can also be described as the
“Nash equilibrium”.
In fact, currently, all surgical treatments can be understood as
“improvement of human internal environment”, and all agent treatments
can be understood as “generalized dietary therapy”, since any drug is
also a “generalized food” for intake to treat human diseases. As we
know, traditional Chinese medicine has the concept of “medicine and
food having the same origin”. Herein, the “magic polypill” or
E(e)SEEDi is indeed a “super-vaccine” and a “super-therapy”. And it
should be positively conducted in current clinical practice (Table 1).
For example, we may adjust self-emotions through behaviours and
activities of our main organs
“brain-ears-eyes-foots-hands-legs-mouth-nose” for major mental disease
including anxiety and depression (Table 2).