Effects of E(e)SEEDi as a “super-vaccine” on blood, cardiac,
and vascular health
According to the recent reports of we media in China, there were a
series of death cases among talented individuals due to cancer, sudden
diseases and major adverse cardiocerebrovascular events (MACCE), such as
acute myocardial infarction (AMI), stroke, sudden cardiac death (SCD),
venous thrombosis (VT). People may feel very sad or even shed thousands
of tears, but more importantly, how to effectively curb the premature
death of young and middle-aged talents one after another? Actually, good
internal and external environment, enough sleep time and good quality,
happy emotion, aerobic exercise, and reasonable and balancing diets, are
helpful in prolonging healthy lifespan. An updated study showed that
sleep quality indeed highly links to cardiovascular disease (CVD) risk
and mortality.3 It also supports that sleep is a core
element of cardiovascular health. Herein, the innovative “magic
polypill” or E(e)SEEDi as one of novel strategies4 is
actually a “super-vaccine” for human health or mass
health,5 particular cardiovascular health due to
improvement of lifestyle and immunity.6
As we all know, CVD remains the most deadly condition and the big burden
and challenges of public health in the globe.7 Both
the number of global CVD deaths and the total number of
disability-adjusted life years due to stroke steadily increased since
1990.8 Currently, there are around 330 million CVD
cases in China due to unhealthy lifestyle and related risk
factors.9 In fact, five modifiable risk factors highly
link to incident CVD and deaths.10 And cardiovascular
mortality far exceeds that of COVID-19 infection, but people’s awareness
of preventing MACCE is almost “numb”. Perhaps it is a new normal, few
individuals are truly aware of the risk of MACCE, in particular the
pandemic and post-COVID-19 era.11,12 In fact, existing
CVD (e.g., hypertension) links to critical cases.13Sincerely and frankly speaking, it’s believed that the economic and
social benefits of the “magic polypill” or E(e)SEEDi in preventing
MACCE actually exceed the role of mRNA vaccines in COVID-19 infection.
Since COVID-19 infection had been effectively controlled, it can be said
that it was the SARS-CoV-2 infection that has made today’s mRNA vaccines
(2023 medicine Nobel ).14 Similarly, year
after year, day in day out, there were one case after another of young
and middle-aged talents’ deaths due to their unhealthy lifestyle related
MACCE. And in fact, these MACCE are more ferocious life “killers”.
Thus, this combinatorial and frugal innovations may have a big success
due to these talents’ unexpected MACCE. Therefore, it’s easy to
understand that the “magic polypill” or E(e)SEEDi is a
“super-vaccine” for human health, particularly young and middle-aged
talents’ health due to improvement of lifestyle and immunity by the role
of the “HE 5” including good diets, e.g., marine natural products
(MNPs) with taurine 15,16 and
traditional Chinese medicine (TCM, e.g.,
Tongxinluo) 17 for cardiovascular health.
An updated definition of health18 is that “good
health is characterized by physical and psychological well-being and is
associated with vitality”. In the post-COVID-19 era,
self-care19 is indeed crucial to individual’s
cardiovascular health. Since unhealthy lifestyle are associated with
higher levels of oxidative stress,20 anxiety and
depression are associated with less ideal cardiovascular health in young
adults.21 In fact, anxiety and depression are common
high-risk conditions in patients with chronic
diseases,22 and especially CVD. However, the healthy
E(e)SEEDi lifestyle, for example, a high sleep quality, a regular
moderate-intensity exercise or physical activity, Mediterranean diet,
and smoking cessation,23,24 is beneficial for
prevention of anxiety and depression and stress-induced cardiovascular
events, and is correlated with lower cardiovascular risk under relieving
these conditions. Herein, the healthy E(e)SEEDi lifestyle may improve
both emotion and cardiovascular health.
In fact, as standard preventive therapies, adults with elevated coronary
artery calcium25 should have the healthy E(e)SEEDi
lifestyle so as to lower risk and delay onset of CVD. Both childhood and
adulthood adversities26 associated risk of CVD later
in life may be effectively prevented by the healthy E(e)SEEDi lifestyle.
A recent study found that gamma-aminobutyric acid
supplementation27 may elicite noteworthy enhancements
in heart rate variability, emotional response, depression mitigation,
and sleep efficiency. Whatever, previous practice confirmed that “more
intensive effort in lifestyle modification, more significant additional
benefit in CVD prevention”.28 For example, active
lifestyle and fitness were protective role on increased post-exercise
albuminuria with hypertension.29 In fact, adherence to
a healthy lifestyle may positively influence levels of endothelial
progenitor cells and exercise capacity.30 But
unhealthy lifestyle (chronic pain, sleep problems, bad emotion, and lack
of exercise) may present as cognitive risk factors in former football
players.31
As we know, inhibitors of antiapoptotic proteins BCL2 and
MCL1,32 the first approved Venetoclax (a specific
inhibitor of BCL2) and the developing BH3 mimetics targeting MCL1, have
promising roles in treatment of hematologic malignancies. However, “the
magic polypill”, that is the E(e)SEEDi, has a crucial value in the
prevention of mNCDs (VT, CVD, diabetes, and cancer) including
hematologic malignancies, since just like the Inmazeb
(REGN-EB3),33 a three-antibody cocktail against Ebola
virus, current data support the benefit of the E(e)SEEDi as “a
cocktail” for mNCDs, particularly blood and vascular health. As a
common, simple and effective biomarker, neutrophil
number34 is widely used in clinical practice for
evaluation of individuals’ conditions. Just as new drugs and
paradigm-changing innovations,35 the E(e)SEEDi
lifestyle may keep human blood and vascular in better conditions.