Effects of E(e)SEEDi as a “super-vaccine” on blood, cardiac, and vascular health
According to the recent reports of we media in China, there were a series of death cases among talented individuals due to cancer, sudden diseases and major adverse cardiocerebrovascular events (MACCE), such as acute myocardial infarction (AMI), stroke, sudden cardiac death (SCD), venous thrombosis (VT). People may feel very sad or even shed thousands of tears, but more importantly, how to effectively curb the premature death of young and middle-aged talents one after another? Actually, good internal and external environment, enough sleep time and good quality, happy emotion, aerobic exercise, and reasonable and balancing diets, are helpful in prolonging healthy lifespan. An updated study showed that sleep quality indeed highly links to cardiovascular disease (CVD) risk and mortality.3 It also supports that sleep is a core element of cardiovascular health. Herein, the innovative “magic polypill” or E(e)SEEDi as one of novel strategies4 is actually a “super-vaccine” for human health or mass health,5 particular cardiovascular health due to improvement of lifestyle and immunity.6
As we all know, CVD remains the most deadly condition and the big burden and challenges of public health in the globe.7 Both the number of global CVD deaths and the total number of disability-adjusted life years due to stroke steadily increased since 1990.8 Currently, there are around 330 million CVD cases in China due to unhealthy lifestyle and related risk factors.9 In fact, five modifiable risk factors highly link to incident CVD and deaths.10 And cardiovascular mortality far exceeds that of COVID-19 infection, but people’s awareness of preventing MACCE is almost “numb”. Perhaps it is a new normal, few individuals are truly aware of the risk of MACCE, in particular the pandemic and post-COVID-19 era.11,12 In fact, existing CVD (e.g., hypertension) links to critical cases.13Sincerely and frankly speaking, it’s believed that the economic and social benefits of the “magic polypill” or E(e)SEEDi in preventing MACCE actually exceed the role of mRNA vaccines in COVID-19 infection.
Since COVID-19 infection had been effectively controlled, it can be said that it was the SARS-CoV-2 infection that has made today’s mRNA vaccines (2023 medicine Nobel ).14 Similarly, year after year, day in day out, there were one case after another of young and middle-aged talents’ deaths due to their unhealthy lifestyle related MACCE. And in fact, these MACCE are more ferocious life “killers”. Thus, this combinatorial and frugal innovations may have a big success due to these talents’ unexpected MACCE. Therefore, it’s easy to understand that the “magic polypill” or E(e)SEEDi is a “super-vaccine” for human health, particularly young and middle-aged talents’ health due to improvement of lifestyle and immunity by the role of the “HE 5” including good diets, e.g., marine natural products (MNPs) with taurine 15,16 and traditional Chinese medicine (TCM, e.g., Tongxinluo) 17 for cardiovascular health.
An updated definition of health18 is that “good health is characterized by physical and psychological well-being and is associated with vitality”. In the post-COVID-19 era, self-care19 is indeed crucial to individual’s cardiovascular health. Since unhealthy lifestyle are associated with higher levels of oxidative stress,20 anxiety and depression are associated with less ideal cardiovascular health in young adults.21 In fact, anxiety and depression are common high-risk conditions in patients with chronic diseases,22 and especially CVD. However, the healthy E(e)SEEDi lifestyle, for example, a high sleep quality, a regular moderate-intensity exercise or physical activity, Mediterranean diet, and smoking cessation,23,24 is beneficial for prevention of anxiety and depression and stress-induced cardiovascular events, and is correlated with lower cardiovascular risk under relieving these conditions. Herein, the healthy E(e)SEEDi lifestyle may improve both emotion and cardiovascular health.
In fact, as standard preventive therapies, adults with elevated coronary artery calcium25 should have the healthy E(e)SEEDi lifestyle so as to lower risk and delay onset of CVD. Both childhood and adulthood adversities26 associated risk of CVD later in life may be effectively prevented by the healthy E(e)SEEDi lifestyle. A recent study found that gamma-aminobutyric acid supplementation27 may elicite noteworthy enhancements in heart rate variability, emotional response, depression mitigation, and sleep efficiency. Whatever, previous practice confirmed that “more intensive effort in lifestyle modification, more significant additional benefit in CVD prevention”.28 For example, active lifestyle and fitness were protective role on increased post-exercise albuminuria with hypertension.29 In fact, adherence to a healthy lifestyle may positively influence levels of endothelial progenitor cells and exercise capacity.30 But unhealthy lifestyle (chronic pain, sleep problems, bad emotion, and lack of exercise) may present as cognitive risk factors in former football players.31
As we know, inhibitors of antiapoptotic proteins BCL2 and MCL1,32 the first approved Venetoclax (a specific inhibitor of BCL2) and the developing BH3 mimetics targeting MCL1, have promising roles in treatment of hematologic malignancies. However, “the magic polypill”, that is the E(e)SEEDi, has a crucial value in the prevention of mNCDs (VT, CVD, diabetes, and cancer) including hematologic malignancies, since just like the Inmazeb (REGN-EB3),33 a three-antibody cocktail against Ebola virus, current data support the benefit of the E(e)SEEDi as “a cocktail” for mNCDs, particularly blood and vascular health. As a common, simple and effective biomarker, neutrophil number34 is widely used in clinical practice for evaluation of individuals’ conditions. Just as new drugs and paradigm-changing innovations,35 the E(e)SEEDi lifestyle may keep human blood and vascular in better conditions.