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Novel rod-like carbon nanomaterials as NIR-responsive drug delivery system for potential anticancer applications
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  • Mengru Liu,
  • Xiaoxue Du,
  • Jingyi Liu,
  • Guangshuo Wang,
  • Jiajia Yang,
  • Xueling Wang,
  • Shuai Han,
  • Zhongchao Huo
Mengru Liu
Hebei University of Engineering
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Xiaoxue Du
Hebei University of Engineering
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Jingyi Liu
Hebei University of Engineering
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Guangshuo Wang
Hebei University of Engineering
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Jiajia Yang
Hebei University of Engineering
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Xueling Wang
Hebei University of Engineering
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Shuai Han
Hebei University of Engineering

Corresponding Author:hansh04@163.com

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Zhongchao Huo
Hebei University of Engineering
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Abstract

The combination of chemotherapy and photothermal therapy shows great potential to achieve synergistic anti-tumor effect. However, it is still a great challenge to design stimuli responsive drug release systems with integrated photothermal/chemotherapy functions. In this paper, novel rod-like carbon nanomaterials (RCNs) were prepared by soft template hydrothermal method with glucose as raw materials, which were proved to have good biocompatibility, excellent drug-loading capacity and high photothermal efficiency. After that, RCNs we used to load doxorubicin (DOX) for integrated photothermal/chemotherapy toward cancer, which demonstrated good treatment efficiency under NIR irradiation. Our approach provided a novel NIR-responsive nano platform for combined photothermal/chemotherapy toward cancer, which was considered to be of great potential in anticancer applications.
03 Nov 2023Submitted to Micro & Nano Letters
09 Nov 2023Submission Checks Completed
09 Nov 2023Assigned to Editor
15 Nov 2023Reviewer(s) Assigned
20 Nov 2023Review(s) Completed, Editorial Evaluation Pending
21 Nov 2023Editorial Decision: Revise Major