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Biomarkers for the Diagnosis, Treatment Follow-Up, and Prediction of Cardiac Complications in Chagas Disease. Recent.
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  • Juan Ospina,
  • M. Morales-Velázquez,
  • J.P. Barón-Vera,
  • M.I. Osorio-Pulgarín,
  • Miryan Sánchez
Juan Ospina
Instituto Colombiano de Medicina Tropical Antonio Roldan Betancur

Corresponding Author:jospina@ces.edu.co

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M. Morales-Velázquez
Instituto Colombiano de Medicina Tropical Antonio Roldan Betancur
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J.P. Barón-Vera
Instituto Colombiano de Medicina Tropical Antonio Roldan Betancur
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M.I. Osorio-Pulgarín
Instituto Colombiano de Medicina Tropical Antonio Roldan Betancur
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Miryan Sánchez
Instituto Colombiano de Medicina Tropical Antonio Roldan Betancur
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Abstract

Chagas disease is caused by the Trypanosoma cruzi parasite and is transmitted by infected triatomine bugs. This infection affects approximately 8 million people in the Americas, and due to globalization and displacement, it is becoming increasingly common to find infected patients worldwide. Diagnosis of the disease in its acute form is relatively simple, as the parasite can be detected in peripheral blood smears, and symptoms are visible. However, in its chronic condition, the parasite is almost undetectable, and indirect tests are necessary to determine the presence of antibodies in infected patients. It is important to note that a single test is not enough to confirm the disease, as a second serological test should confirm the diagnosis. If the results are contradictory, a third test should be performed to solve the problem. Unfortunately, laboratories may not have access to all necessary tests in many rural areas where the disease is more frequent. Rapid tests to diagnose this disease present problems, such as significant variations in sensitivity and specificity in different countries. Therefore, searching for new biomarkers that allow for optimal correlation is essential. In this work, we have searched scientific literature from the last years for mentions of novel biomarkers for diagnosis, treatment follow-up, and prediction of cardiac complications in Chagas disease in its chronic phase.
16 May 2023Submitted to Parasite Immunology
16 May 2023Submission Checks Completed
16 May 2023Assigned to Editor
16 May 2023Review(s) Completed, Editorial Evaluation Pending
16 May 2023Reviewer(s) Assigned
24 Jul 2023Editorial Decision: Revise Minor
09 Sep 20231st Revision Received
09 Sep 2023Submission Checks Completed
09 Sep 2023Assigned to Editor
09 Sep 2023Review(s) Completed, Editorial Evaluation Pending
19 Sep 2023Editorial Decision: Accept