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Unfolded Protein Response (UPR) Pathway in cutaneous leishmaniasis: A review
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  • Nadira Karunaweera,
  • Nimesha Madhushani Edirisinghe,
  • Nuwani Manamperi,
  • Vishmi Samudika Wanasinghe
Nadira Karunaweera
University of Colombo Faculty of Medicine

Corresponding Author:nadira@parasit.cmb.ac.lk

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Nimesha Madhushani Edirisinghe
University of Colombo Faculty of Medicine
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Nuwani Manamperi
University of Kelaniya Faculty of Medicine
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Vishmi Samudika Wanasinghe
University of Colombo Faculty of Medicine
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Abstract

Alteration in the physiological state of the endoplasmic reticulum (ER) leads to the specific response known as unfolded protein response (UPR) or ER stress response. The UPR is driven by three sensor proteins, namely: Inositol Requiring Enzyme 1 (IRE1), Protein Kinase RNA like ER kinase (PERK), and Activating Transcription Factor 6 (ATF6) to restore ER homeostasis. Pathogenic infection can initiate UPR activation; some pathogens can subvert the UPR to promote their survival and replication. Many intracellular pathogens, including Leishmania, can interact and hijack ER for their survival and replication, triggering ER stress and subsequently ER stress response. This review aims to provide a comprehensive overview of the ER stress response in infections with the Leishmania species .
24 Apr 2023Submitted to Parasite Immunology
24 Apr 2023Submission Checks Completed
24 Apr 2023Assigned to Editor
24 Apr 2023Review(s) Completed, Editorial Evaluation Pending
24 Apr 2023Reviewer(s) Assigned
04 Jul 2023Editorial Decision: Revise Minor
26 Jul 20231st Revision Received
26 Jul 2023Review(s) Completed, Editorial Evaluation Pending
26 Jul 2023Submission Checks Completed
26 Jul 2023Assigned to Editor
26 Jul 2023Editorial Decision: Accept