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Association between SARS-CoV-2 Infections during Pregnancy and Preterm Live Birth
  • +14
  • Sarita Mohanty,
  • Alan Tita,
  • Michael Varner,
  • Melissa Stockwell,
  • Gabriella Newes-Adeyi,
  • Ashley Battarbee,
  • Lawrence Reichle,
  • Tyler Morrill,
  • Michael Daugherty,
  • Mirella Mourad,
  • Raul Silverio Francisco,
  • Kate Woodworth,
  • Kristina Wielgosz,
  • Romeo Galang,
  • Pete Maniatis,
  • Vera Semenova,
  • Fatimah Dawood
Sarita Mohanty
Centers for Disease Control and Prevention

Corresponding Author:smohanty@cdc.gov

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Alan Tita
UAB School of Medicine
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Michael Varner
The University of Utah Health Sciences Center
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Melissa Stockwell
Columbia University Medical Center
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Gabriella Newes-Adeyi
ABT Associates Inc
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Ashley Battarbee
UAB School of Medicine
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Lawrence Reichle
ABT Associates Inc
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Tyler Morrill
ABT Associates Inc
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Michael Daugherty
Centers for Disease Control and Prevention
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Mirella Mourad
Columbia University Medical Center
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Raul Silverio Francisco
Columbia University Medical Center
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Kate Woodworth
Centers for Disease Control and Prevention
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Kristina Wielgosz
Centers for Disease Control and Prevention
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Romeo Galang
Centers for Disease Control and Prevention
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Pete Maniatis
Centers for Disease Control and Prevention
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Vera Semenova
Centers for Disease Control and Prevention
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Fatimah Dawood
Centers for Disease Control and Prevention
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Abstract

We examined associations between mild or asymptomatic prenatal SARS-CoV-2 infection and preterm live birth in a prospective cohort study. During August 2020–October 2021, pregnant persons were followed with systematic surveillance for RT-PCR or serologically-confirmed SARS-CoV-2 infection until pregnancy end. The association between prenatal SARS-CoV-2 infection and preterm birth was assessed using Cox proportional-hazards regression. Among 954 pregnant persons with a live birth, 185 (19%) had prenatal SARS-CoV-2 infection and 123 (13%) had preterm birth. The adjusted hazard ratio for the association between SARS-CoV-2 infection and preterm birth was 1.28 (95% confidence interval 0.82-1.99, p=0.28), although results did not reach statistical significance.
08 Mar 2023Submitted to Influenza and other respiratory viruses
09 Mar 2023Submission Checks Completed
09 Mar 2023Assigned to Editor
11 Mar 2023Reviewer(s) Assigned
02 Jul 2023Review(s) Completed, Editorial Evaluation Pending
05 Jul 2023Editorial Decision: Revise Minor
27 Jul 20231st Revision Received
31 Jul 2023Submission Checks Completed
31 Jul 2023Assigned to Editor
09 Aug 2023Editorial Decision: Accept