loading page

Investigating racial disparities in quality of life years after pediatric hematopoietic stem cell transplant
  • +13
  • Alexander Ngwube,
  • Anuj Shah,
  • Christina Regan,
  • Serena Suwarno,
  • Janet Foote,
  • Victoria Bernaud,
  • Jennifer Stahlecker,
  • Holly Miller,
  • Natalie Booth,
  • Daniella Giralt,
  • Dana Salzberg,
  • Mohamad G. Sinno,
  • Courtney Campbell,
  • Kristen Beebe,
  • Charlotte Schwalbach,
  • Roberta Adams
Alexander Ngwube
The University of Arizona College of Medicine Phoenix

Corresponding Author:angwube@phoenixchildrens.com

Author Profile
Anuj Shah
University of Miami School of Medicine
Author Profile
Christina Regan
The University of Arizona College of Medicine Phoenix
Author Profile
Serena Suwarno
The University of Arizona College of Medicine Phoenix
Author Profile
Janet Foote
The University of Arizona College of Medicine Phoenix
Author Profile
Victoria Bernaud
Phoenix Children's Hospital
Author Profile
Jennifer Stahlecker
Phoenix Children's Hospital
Author Profile
Holly Miller
The University of Arizona College of Medicine Phoenix
Author Profile
Natalie Booth
Phoenix Children's Hospital
Author Profile
Daniella Giralt
Phoenix Children's Hospital
Author Profile
Dana Salzberg
Phoenix Children's Hospital
Author Profile
Mohamad G. Sinno
Phoenix Children's Hospital
Author Profile
Courtney Campbell
Phoenix Children's Hospital
Author Profile
Kristen Beebe
Phoenix Children's Hospital
Author Profile
Charlotte Schwalbach
Phoenix Children's Hospital
Author Profile
Roberta Adams
Phoenix Children's Hospital
Author Profile

Abstract

Background While racial disparities in the clinical outcomes of hematopoietic stem cell transplant (HSCT) patients have been explored, racial disparities in quality of life (QoL) during the readjustment phase after transplant has yet to be investigated in pediatric patients. The objective of this study was to examine the role of patient race in QoL at least two years after pediatric HSCT. Procedure We conducted a retrospective chart review of patients under 21 years of age at diagnosis that received an allogeneic transplant at our institution between January 2007 and December 2017. Patient QoL was assessed using the PedsQL TM 4.0 at least two years post-transplant. Patient demographic, treatment, and transplant outcome data were obtained for subsequent analysis, where patient race was categorized as either Black, White, Hispanic, or Native American. Results Data were collected on 86 pediatric patients who underwent HSCT. Forty patients (46.5%) were non-Hispanic White, 29 (33.7%) Hispanic, 10 (11.6%) Black, and 7 (8.1%) Native American. Where preliminary analyses indicated a difference in QoL by patient race, there were no significant differences in physical, emotional, social, and school functioning by patient race after adjusting for transplant characteristics (age at transplant, sex, diagnosis, donor type and conditioning regimen) and determinants of socioeconomic status (insurance type, estimated household income). Conclusions Pediatric patients had comparable QoL, regardless of race, at a median of three years after HSCT in our study cohort.
02 Mar 2023Submission Checks Completed
02 Mar 2023Assigned to Editor
02 Mar 2023Submitted to Pediatric Blood & Cancer
02 Mar 2023Review(s) Completed, Editorial Evaluation Pending
07 Mar 2023Reviewer(s) Assigned
10 Apr 2023Editorial Decision: Revise Minor
11 May 2023Submission Checks Completed
11 May 2023Assigned to Editor
11 May 20231st Revision Received
12 May 2023Review(s) Completed, Editorial Evaluation Pending
15 May 2023Reviewer(s) Assigned
01 Jun 2023Editorial Decision: Accept