Study population and data source
This study includes patients aged 21 years or younger at the time of diagnosis who received an allogeneic transplant between January 2007 and December 2017 at our 457-bed children’s hospital in Phoenix, Arizona. QoL questionnaires that capture patient readjustment were collected longitudinally using the Pediatric Quality of Life Inventory Generic Score Scales (PedsQL TM 4.0) from 2013 to 2017. Patients were excluded if they did not have post-transplant QoL data, as defined by a completed PedsQL TM 4.0, at least two years after HSCT. Considering surveys of patients at least two years after HSCT provided patients with sufficient time to experience adjustments in QoL as expected in early post-HSCT life. For patients with multiple transplants, transplant-specific data from the first transplant was used, but the most recent PedsQL TM 4.0 was used for QoL metrics. A total of 184 patients received HSCT at our hospital between January 2007 and December 2017. Of this, 86 (46.7%) patients completed the PedsQL TM 4.0, and were therefore included in the study. Of these patients, 79 patients (91.86%) received one transplant and 7 patients (8.14%) received two transplants. All patient demographic, treatment, and transplant outcome data were obtained retrospectively through medical chart review. All study procedures were approved by our Institutional Review Board.