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Incidence, hospitalization, and mortality in children aged five years and younger with respiratory syncytial virus-related diseases: A systematic review and meta-analysis
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  • Yuping Duan,
  • Mingyue Jiang,
  • Qiangru Huang,
  • Mengmeng Jia,
  • Weizhong Yang,
  • Luzhao Feng
Yuping Duan
Chinese Academy of Medical Sciences & Peking Union Medical College
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Mingyue Jiang
Chinese Academy of Medical Sciences & Peking Union Medical College
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Qiangru Huang
Chinese Academy of Medical Sciences & Peking Union Medical College
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Mengmeng Jia
Chinese Academy of Medical Sciences & Peking Union Medical College
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Weizhong Yang
Chinese Academy of Medical Sciences & Peking Union Medical College
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Luzhao Feng
Chinese Academy of Medical Sciences & Peking Union Medical College

Corresponding Author:fengluzhao@cams.cn

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Abstract

Objectives: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection in young children. We aimed to analyze the factors affecting the estimation of RSV-related disease burden, and furthermore, to provide evidence to help establish a surveillance system. Methods: We searched for literature published in English or Chinese between 1 January, 2010 and 2 June, 2022. The quality of the included articles was assessed using the Agency for Healthcare Research and Quality scale. Random-effects models were used for data synthesis and subgroup analyses. This review was registered in the Prospective Register of Systematic Reviews (PROSPERO: CRD42022372972). Results: We included 44 studies (149,321,171 participants), all of which were of medium or high quality. The pooled RSV-associated disease incidence, hospitalization rate, in-hospital mortality, and overall mortality rates in children aged 5 years and younger were 9.0% (95% confidence interval [CI]: 7.0–11.0%), 1.68% (95% CI: 1.30–2.05%), 0.45% (95% CI: 0.38–0.52%), and 0.05% (95% CI: 0.04–0.06%), respectively. Age, economics, surveillance types, case definition, and data source were all influencing factors. Conclusions: A standardized and unified RSV surveillance system is required. Case definition and surveillance types should be fully considered for surveillance of different age groups.
15 Feb 2023Submitted to Influenza and other respiratory viruses
15 Feb 2023Submission Checks Completed
15 Feb 2023Assigned to Editor
10 Mar 2023Reviewer(s) Assigned
12 Apr 2023Review(s) Completed, Editorial Evaluation Pending
12 Apr 2023Editorial Decision: Revise Major
24 Apr 20231st Revision Received
26 Apr 2023Submission Checks Completed
26 Apr 2023Assigned to Editor
03 May 2023Editorial Decision: Accept