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Coronary microcirculation and left ventricular diastolic function but not myocardial deformation indices are impaired early in patients with chronic kidney disease
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  • Aris Bechlioulis,
  • Lampros Lakkas,
  • Katerina Naka,
  • Annila Duni,
  • Chariklia Gouva,
  • Olga Balafa,
  • Vasileios Koutlas,
  • Christos Katsouras,
  • Evangelia Dounousi,
  • Lampros Michalis
Aris Bechlioulis
Panepistemiako Geniko Nosokomeio Ioanninon
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Lampros Lakkas
Panepistemiako Geniko Nosokomeio Ioanninon
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Katerina Naka
Panepistemiako Geniko Nosokomeio Ioanninon

Corresponding Author:drkknaka@gmail.com

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Annila Duni
Panepistemiako Geniko Nosokomeio Ioanninon
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Chariklia Gouva
Panepistemiako Geniko Nosokomeio Ioanninon
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Olga Balafa
Panepistemiako Geniko Nosokomeio Ioanninon
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Vasileios Koutlas
Panepistemiako Geniko Nosokomeio Ioanninon
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Christos Katsouras
Panepistemiako Geniko Nosokomeio Ioanninon
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Evangelia Dounousi
Panepistemiako Geniko Nosokomeio Ioanninon
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Lampros Michalis
Panepistemiako Geniko Nosokomeio Ioanninon
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Abstract

Aim. To investigate abnormalities in myocardial strain and classic echocardiographic indices and coronary flow reserve (CFR), in younger vs older CKD patients. Methods. Sixty consecutive CKD patients (<60 years old n=30, ≥60 years old n=30) and 30 healthy controls (age- and gender-matched with younger CKD patients) were recruited. An echocardiographic assessment including myocardial strain indices was performed at baseline and following dipyridamole administration in all participants. Results. Younger CKD patients had higher E/e’, left ventricular mass index and relative wall thickness and lower E’ (p<0.005 for all) compared to healthy controls. Older CKD patients had lower E/A and E’ (p<0.05 for both) compared to younger CKD patients; these differences did not remain significant after adjustment for age. CFR was higher in healthy controls compared to younger and older CKD patients (p<0.05 for both) without a significant difference between CKD groups. Dipyridamole-induced changes did not differ significantly among the 3 groups. Conclusions. Compared to healthy controls, impaired coronary microcirculation and left ventricular diastolic function, but not myocardial strain abnormalities, are found in young CKD patients and deteriorate with aging.
20 Dec 2022Submitted to Echocardiography
29 Dec 2022Submission Checks Completed
29 Dec 2022Assigned to Editor
02 Feb 2023Reviewer(s) Assigned
27 Feb 2023Review(s) Completed, Editorial Evaluation Pending
22 Mar 2023Editorial Decision: Revise Minor
18 Apr 20231st Revision Received
24 Apr 2023Submission Checks Completed
24 Apr 2023Assigned to Editor
24 Apr 2023Reviewer(s) Assigned
02 May 2023Review(s) Completed, Editorial Evaluation Pending
03 May 2023Editorial Decision: Accept