loading page

The outcome of Peripartum Cardiomyopathy Patients-Single Center Experience
  • +10
  • Emre Demir,
  • Naim Ceylan,
  • Selen Bayraktaroğlu,
  • Akın Çinkooğlu,
  • Aytaç Candemir,
  • Yeşim B. Candemir,
  • Mustafa Talha Güneş,
  • Şevket Yeniyol,
  • Elfin B. Yılmaz,
  • Mehdi Zaoghi,
  • Azem Akıllı,
  • cemil gurgun,
  • Sanem Nalbantgil
Emre Demir
Ege Universitesi

Corresponding Author:emre.demir.ege@gmail.com

Author Profile
Naim Ceylan
Ege Universitesi
Author Profile
Selen Bayraktaroğlu
Ege Universitesi
Author Profile
Akın Çinkooğlu
Ege Universitesi
Author Profile
Aytaç Candemir
Ege Universitesi
Author Profile
Yeşim B. Candemir
Ege Universitesi
Author Profile
Mustafa Talha Güneş
Ege Universitesi
Author Profile
Şevket Yeniyol
Ege Universitesi
Author Profile
Elfin B. Yılmaz
Ege Universitesi
Author Profile
Mehdi Zaoghi
Ege Universitesi
Author Profile
Azem Akıllı
Ege Universitesi
Author Profile
cemil gurgun
Ege Universitesi
Author Profile
Sanem Nalbantgil
Ege Universitesi
Author Profile

Abstract

Objective: Peripartum cardiomyopathy (PPCM) diagnosis made by excluding identifiable causes of heart failure (HF) and occurs end of the pregnancy or during the postpartum period of five months. It presents a clinical HF spectrum with left ventricular systolic dysfunction. Background: The purpose of this study is to retrospectively evaluate the clinical characteristics, cardiac magnetic resonance (CMR) imaging features, and end-points consisting of left ventricle recovery, left ventricular assist device implantation, heart transplantation, and all-cause mortality. Method: Outpatient HF records between 2008 to 2021 were screened. Thirty-seven patients were defined as PPCM. Twenty-five patients had CMR evaluation at the time of diagnosis, and six patients were re-evaluated with CMR. Results: The mean age was 30.5±5.6 years, and the mean LVEF was 28.2±6.7%. In thirteen(35.7%) patients, LVEF recovered during the follow-up course. The median recovery time was 281(IQR [78-358]) days. LVEF on CMR was 35.3±10.5, and three patients exhibited late gadolinium enhancement(LGE) patterns. Sub-endocardial and mid-wall uptake pattern types were detected. 18(75%) patients met the Petersen left ventricle non-compaction cardiomyopathy(LVNC) criteria. Patients with NC/C ratio lower than 2.3 had lower LVEDVi and LVESVi (124.9±35.4,86.4±7.5, p=0.003;86.8±34.6,52.6±7.6, p=0.006), respectively. The median follow-up time was 2129 (IQR [911-2634]) days. The primary endpoint-free one-year survival was 88.9%(event rate 11.1%), and five-year survival was 75.7%(event rate 24.3%). Conclusion: In a retrospective cohort of PPCM patients, 35.7% of patients’ LVEF recovered, and the primary end-point of free-five-year survival was 75%. Twenty-five patients were assessed with CMR; three of four met the Petersen CMR-derived LVNC at initial evaluation.
22 Aug 2022Submitted to Echocardiography
22 Aug 2022Submission Checks Completed
22 Aug 2022Assigned to Editor
02 Sep 2022Reviewer(s) Assigned
02 Oct 2022Editorial Decision: Accept