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Left Ventricular Strain in Neonates using 2-dimensional speckle tracking: Normal range and relation with bi-plan Ejection fraction.
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  • Khaled Al Nahili,
  • Irfan Saleem,
  • Salim Ahmad,
  • El Tayeb Ahmed,
  • Najlaa Al Rajaa
Khaled Al Nahili
Prince Sultan Cardiac Center

Corresponding Author:khaled.059@hotmail.com

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Irfan Saleem
Prince Sultan Cardiac Center
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Salim Ahmad
Prince Sultan Cardiac Center
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El Tayeb Ahmed
Prince Sultan Cardiac Center
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Najlaa Al Rajaa
Prince Sultan Cardiac Center
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Abstract

Objectives: Echocardiographic assessment of Left ventricular systolic function is traditionally being performed by estimation of fractional shortening and Ejection fraction. Speckle tracking echocardiography (STE) is a promising tool for assessment of myocardial function. The aim of this study is to evaluate the global longitudinal strain (GLS) using 2D-STE in healthy neonates to establish normal reference ranges. Method: it is a retrospective study through an analysis of transthoracic echocardiogram of normal healthy neonates. We enrolled all neonates in our institution from 1 st January 2021 to 28 th February 2021. 2-D STE was used to assess left ventricular global longitudinal strain from the apical views. Results: 185 neonates were enrolled. Mean value for left ventricle GLS (%) was -19.9 ± 1.2, GLS-derived ejection fraction (%) was 60.0 ± 2.7; while the left ventricle ejection fraction by biplane Simpson’s method (%) was 61.0 ± 3. There is a good positive correlation between the Left Ventricle EF by biplane Simpson’s method and EF by 2-D STE, which was statistically significant ( r = 0.294,  n = 102,  p=0.003). Apical 4-chamber longitudinal strain and strain derived EF is significantly correlated with GLS and bi-plan EF respectively. Conclusion: 2-STE is feasible technique for analyzing newborn myocardial systolic function. The normal range of GLS in neonates is not much different than reported for the pediatric. There is a good positive correlation between the Left Ventricle EF by 2-D STE and EF by biplane method.
14 Mar 2022Submitted to Echocardiography
08 Apr 2022Submission Checks Completed
08 Apr 2022Assigned to Editor
10 Apr 2022Reviewer(s) Assigned
26 Apr 2022Review(s) Completed, Editorial Evaluation Pending
07 May 2022Editorial Decision: Revise Minor
23 May 20221st Revision Received
25 May 2022Submission Checks Completed
25 May 2022Assigned to Editor
25 May 2022Reviewer(s) Assigned
08 Jun 2022Review(s) Completed, Editorial Evaluation Pending
13 Jun 2022Editorial Decision: Accept
Aug 2022Published in Echocardiography volume 39 issue 8 on pages 1074-1081. 10.1111/echo.15414