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Forced Expiratory Flows and Diffusion Capacity in Infants Born from Mothers with Pre-eclampsia
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  • Clement Ren,
  • James Slaven,
  • David Haas,
  • Laura Haneline,
  • Christina Tiller,
  • Graham Hogg,
  • Jeffrey Bjerregaard,
  • Robert Tepper
Clement Ren
The Children's Hospital of Philadelphia

Corresponding Author:renc@chop.edu

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James Slaven
Indiana University School of Medicine
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David Haas
Indiana University School of Medicine
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Laura Haneline
James Whitcomb Riley Hospital for Children
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Christina Tiller
James Whitcomb Riley Hospital for Children
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Graham Hogg
Indiana University School of Medicine
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Jeffrey Bjerregaard
Indiana University School of Medicine
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Robert Tepper
Indiana University School of Medicine
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Abstract

Rationale: Animal models suggest pre-eclampsia (Pre-E) affects alveolar development, but data from humans are lacking. Objective: Assess the impact of Pre-E on airway function, diffusion capacity, and respiratory morbidity in preterm and term infants born from mothers with Pre-E. Methods: Infants born from mothers with and without Pre-E were recruited for this study; term and preterm infants were included in both cohorts. Respiratory morbidity in the first 12 months of life was assessed through monthly phone surveys. Raised volume rapid thoracoabdominal compression and measurement of diffusion capacity of the lung to carbon monoxide (DLCO)) were performed at 6 months corrected age. Results: There were 146 infants in the Pre-E cohort and 143 in the control cohort. The Pre-E cohort was further divided into non-severe (N=41) and severe (N=105) groups. There was no significant difference in DCLO and DLCO/aveolar volume amongst the three groups. Forced vital capacity was similar amongst the three groups, but the non-severe Pre-E group had significantly higher forced expiratory flows that the other two. After adjusting for multiple covariates including prematurity, the severe Pre-E group had a lower risk for wheezing in the first year of life compared to the other two. Conclusions: Pre-E is not associated with reduced DLCO, lower forced expiratory flows, or increased wheezing in the first year of life. These results differ from animal models and highlight the the complex relationships between Pre-E and lung function and respiratory morbidity in human infants.
30 Mar 2022Submitted to Pediatric Pulmonology
31 Mar 2022Submission Checks Completed
31 Mar 2022Assigned to Editor
02 Apr 2022Reviewer(s) Assigned
22 Apr 2022Review(s) Completed, Editorial Evaluation Pending
22 Apr 2022Editorial Decision: Revise Major
25 Jun 20221st Revision Received
30 Jun 2022Submission Checks Completed
30 Jun 2022Assigned to Editor
30 Jun 2022Reviewer(s) Assigned
30 Jun 2022Review(s) Completed, Editorial Evaluation Pending
01 Jul 2022Editorial Decision: Accept
Oct 2022Published in Pediatric Pulmonology volume 57 issue 10 on pages 2481-2490. 10.1002/ppul.26064