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Could SARS-CoV-2 Infection Change Fetal Cardiac Output?
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  • Ezgi Turgut,
  • Bedri Sakcak,
  • D.UYAN HENDEM,
  • Deniz Oluklu,
  • Sule Goncu Ayhan,
  • Dilek Sahin
Ezgi Turgut
Division of Perinatology Department of Obstetrics and Gynecology Ministry of Health Ankara City Hospital Ankara Turkey

Corresponding Author:ezgi_sariakcali@hotmail.com

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Bedri Sakcak
Division of Perinatology Department of Obstetrics and Gynecology Ministry of Health Ankara City Hospital Ankara Turkey
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D.UYAN HENDEM
Division of Perinatology Department of Obstetrics and Gynecology Ministry of Health Ankara City Hospital Ankara Turkey
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Deniz Oluklu
Division of Perinatology Department of Obstetrics and Gynecology Ministry of Health Ankara City Hospital Ankara Turkey
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Sule Goncu Ayhan
Division of Perinatology Department of Obstetrics and Gynecology Ministry of Health Ankara City Hospital Ankara Turkey
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Dilek Sahin
Division of Perinatology Department of Obstetrics and Gynecology Ministry of Health Ankara City Hospital Ankara Turkey
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Abstract

Aim: We aimed to examine fetal cardiac output (CO) in patients who recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Materials: This prospective study included 48 pregnant women recovered from SARS-CoV-2 infection and 50 control cases. SARS-CoV-2 infection was diagnosed by polymerase chain reaction (PCR) test in patients. Fetal echocardiographic evaluations were performed at 24-37 weeks of gestation in pregnant women who recovered from the infection and control group. Results: The median value of ultrasound evaluation was 34 (2.6) weeks of gestation in the recovery from the SARS-CoV-2 infection (RSI) group, and 32 (7.6) weeks in the control group (p=0.565). Left cardiac output (LCO) z score was significantly lower in the RSI group than the control group (p=0,041). LCO and combine cardiac output (CCO) z score were significantly lower in the severe disease group than mild, moderate disease groups, and controls (p=0,019 and p=0,013). CCO (mL/min/kg) was decreased in the severe disease group when compared with control and mild disease groups (p=0,044). Fetal distress, preterm delivery rate, and neonatal intensive care unit (NICU) admission were found to be higher in the severe disease group compared to the control group (p=0,010, p=0,009, and p<0,001 respectively). Conclusion: In the present study, fetal cardiac output in pregnant women with recovery from SARS-CoV-2 infection was found significantly decreased, especially in whom had severe diseases. Placental dysfunction and inflammatory cytokines might cause fetal cardiac changes. Further studies could be clarified on the impact of SARS-CoV-2 infection on fetal cardiac function.
22 Feb 2022Submitted to Echocardiography
23 Feb 2022Submission Checks Completed
23 Feb 2022Assigned to Editor
06 Mar 2022Reviewer(s) Assigned
26 Mar 2022Review(s) Completed, Editorial Evaluation Pending
30 Mar 2022Editorial Decision: Revise Major
08 Apr 20221st Revision Received
18 Apr 2022Submission Checks Completed
18 Apr 2022Assigned to Editor
18 Apr 2022Reviewer(s) Assigned
25 Apr 2022Review(s) Completed, Editorial Evaluation Pending
03 May 2022Editorial Decision: Accept