We report a rare case of multiple giant coronary artery aneurysms combined with anomalous aortic origin of left coronary artery in a 30-years old man precisely diagnosed by multimodality imaging, including echocardiography, coronary computed tomographic angiography (CCTA), cardiac magnetic resonance imaging (CMR) and selective coronary angiography. The imaging results were finally confirmed by surgery. We present the clinical value of multimodality imaging in diagnosing coronary artery aneurysm and anomalous origin.