loading page

Fast Assessment of Left Ventricular Systolic Function in Obstructive Sleep Apnea Patients with Automated Function Imaging: Comparison with Mitral Annular Plane Systolic Excursion
  • +6
  • ChenYao Ma,
  • John Sanderson,
  • Qi Chen,
  • Zhe Liang,
  • XiaoJun Zhan,
  • Chan Wu,
  • Hu Liu,
  • Lei Xiao,
  • Fang Fang
ChenYao Ma
Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases

Corresponding Author:machenyao888@163.com

Author Profile
John Sanderson
Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases
Author Profile
Qi Chen
Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases
Author Profile
Zhe Liang
Beijing Anzhen Hospital, Department of Cardiology, Capital Medical University
Author Profile
XiaoJun Zhan
Beijing Anzhen Hospital, Capital Medical University, Heart Lung and Blood Vessel Diseases
Author Profile
Chan Wu
Beijing Anzhen Hospital, Capital Medical University, Heart Lung and Blood Vessel Diseases
Author Profile
Hu Liu
Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases
Author Profile
Lei Xiao
Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases
Author Profile

Abstract

Background: Early cardiovascular impairment in obstructive sleep apnea (OSA) patients is often overlooked, leading to irreversible outcome. Left ventricular (LV) global longitudinal strain (GLS) derived from automated function imaging (AFI) echocardiography provides a fast tool to assess global longitudinal function. We therefore aimed to compare the feasibility and reproducibility of AFI with mitral annulus plane systolic excursion (MAPSE) as obesity is common in OSA. Methods: A comprehensive echocardiographic examination was done in 186 consecutive patients having polysomnography for suspected OSA in this prospective study. MAPSE was measured by using M-mode. AFI was derived by offline analysis of three long-axis views that semi-automatically detects LV endocardial boundary, which is adjusted manually as necessary. Variability of AFI and MAPSE were compared among the different subgroups and further tested in BMI subgroups. Results: Despite a relatively high obesity rate (42.9%), AFI was feasible in 94% (175/186) patients and MAPSE could be recorded in all patients. Although more segments were measured with AFI it showed excellent correlation (r=0.882) superior to MAPSE (r=0.819) between the expert and beginner. Intra- and inter- observer variability of AFI were comparable with MAPSE in Bland-Altman analysis, 5.5% and 6.5% for AFI, 6.2% and 8.8% for MAPSE, respectively. In repeated measurements, AFI showed higher intra-class correlation (ICC=0.95) than MAPSE (ICC=0.87). Furthermore, analysis showed that AFI was feasible even in more obese patients (BMI≥28kg/m2). Conclusions: Even in obese patients with OSA, AFI-GLS is feasible and more reliable for less expert operators than MAPSE for detecting LV longitudinal dysfunction.
20 Jun 2021Submitted to Echocardiography
05 Aug 2021Submission Checks Completed
05 Aug 2021Assigned to Editor
18 Sep 2021Reviewer(s) Assigned
12 Oct 2021Review(s) Completed, Editorial Evaluation Pending
02 Nov 2021Editorial Decision: Revise Major
17 Dec 20211st Revision Received
17 Dec 2021Submission Checks Completed
17 Dec 2021Assigned to Editor
17 Dec 2021Reviewer(s) Assigned
27 Dec 2021Review(s) Completed, Editorial Evaluation Pending
01 Jan 2022Editorial Decision: Accept
Mar 2022Published in Echocardiography volume 39 issue 3 on pages 426-433. 10.1111/echo.15308