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Incidence density of influenza illness during pregnancy in Suzhou, China, 2015--2018
  • +15
  • Liling Chen,
  • Suizan Zhou,
  • Lin Bao,
  • Alexander Millman,
  • Zhongwei Zhang,
  • Yan Wang,
  • Yayun Tan,
  • Ying Song,
  • Pengwei Cui,
  • Yuanyuan Pang,
  • Cheng Liu,
  • Jiangchun Qin,
  • Ping Zhang,
  • Mark Thompson,
  • Angela Iuliano,
  • Ran Zhang,
  • Carolyn Greene,
  • Jun Zhang
Liling Chen
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China

Corresponding Author:liling_chen@163.com

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Suizan Zhou
Centers for Disease Control and Prevention
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Lin Bao
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Alexander Millman
Centers for Disease Control and Prevention
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Zhongwei Zhang
Suzhou Municipal Hospital, Suzhou, Jiangsu Province, P.R. China
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Yan Wang
Wuzhong Maternal and Child Health Care Institute, Suzhou, Jiangsu Province, P.R. China
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Yayun Tan
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Ying Song
U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA
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Pengwei Cui
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Yuanyuan Pang
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Cheng Liu
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Jiangchun Qin
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Ping Zhang
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Mark Thompson
Centers for Disease Control and Prevention
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Angela Iuliano
CDC
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Ran Zhang
U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA
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Carolyn Greene
U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA
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Jun Zhang
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Abstract

Background: Data on influenza incidence during pregnancy in China are limited. Methods: From October 2015–September 2018, we conducted active surveillance for acute respiratory illness (ARI) among women during pregnancy. Nurses conducted twice weekly phone and text message follow-up upon enrollment until delivery to identify new episodes of ARI. Nasal and throat swabs were collected ≤10 days from illness onset to detect influenza. Results: In total, we enrolled 18,724 pregnant women median aged 28yo, 37% in first trimester, 48% in second trimester and 15% in third trimester, with 7 self-reported vaccination during pregnancy. In the 18-week epidemic period during October 2015–September 2016, influenza incidence was 0.7/100 person-months (95% CI:0.5–0.9). In the 29-week epidemic during October 2016–September 2017, influenza incidence was 1.0/100 person-months (95% CI:0.8–1.2). In the 11-week epidemic period during October 2017–September 2018, influenza incidence was 2.1/100 person-months (95% CI:1.9–2.4). Influenza incidence was similar by trimester. More than half of the total influenza illnesses had no elevated temperature and cough. Most influenza-associated ARIs were mild, and <5.1% required hospitalization. Conclusions: Influenza illness in all trimesters of pregnancy was common. These data may help inform decisions regarding the use of influenza vaccine to prevent influenza during pregnancy.
26 May 2021Submitted to Influenza and other respiratory viruses
27 May 2021Submission Checks Completed
27 May 2021Assigned to Editor
02 Jun 2021Editorial Decision: Revise Minor
09 Jun 20211st Revision Received
19 Jun 2021Submission Checks Completed
19 Jun 2021Assigned to Editor
24 Jun 2021Editorial Decision: Accept