The MYB family has been extensively studied in model organisms, but research on them in vegetable crops such as cabbage ( Brassica oleracea L. var. capitata L.) still needs to be supplemented and improved. We cloned BoMYB2 and further determined its role in the response of cabbage to drought stress. We found that the overexpression of BoMYB2, which is induced by ABA, can significantly enhance the drought stress tolerance of cabbage, and the opposite phenotype was observed in BoMYB2 - silenced lines. Two proteins, BoMYC2 and BoAREB1, that interact with BoMYB2 were verified through yeast two - hybrid, luciferase complementation assay, pull - down assay, etc. Overexpressing them in Arabidopsis thaliana significantly improved the drought stress tolerance of A. thaliana. Transient silencing of them in cabbage seedlings reduced the plant’s drought tolerance. Both of them are also induced by ABA, and they cooperate with BoMYB2 to promote the antioxidant capacity of plants under drought stress, affect the expression of downstream genes, and increase the survival rate of plants in drought environments. In summary, our results indicate that BoMYB2 - BoMYC2 and BoMYB2 - BoAREB1 play important roles in the ABA - signal - mediated drought regulation process of cabbage.