Key Clinical MessagePersistent neck swelling in children, unresponsive to initial treatments like anti-tuberculosis therapy, should raise suspicion for malignancies such as nasopharyngeal carcinoma. Early diagnosis and prompt multidisciplinary treatment, including concurrent chemoradiation therapy, are crucial for improving prognosis and ensuring favorable outcomes.Keywords: Neck swelling, Nasopharyngeal carcinoma, Otorhinolaryngology, Pediatric oncology.