The goal of our study is to assess sleep duration and quality during inpatient treatment of an acute pulmonary exacerbation in people with cystic fibrosis (PwCF). We hypothesize that markers of sleep quality will improve with improvement of their lung function. We performed a prospective cohort study of 17 PwCF ages 6 to 21 years old who were admitted for a 14-day hospitalization for a pulmonary exacerbation. Demographics, body mass index, medication, and FEV1 at baseline, during, end, and after hospitalization were collected. Actigraphy and the Patient-Reported Outcomes Measurement Information System (PROMIS) sleep questionnaires at the beginning and end of their hospitalization were used to measure sleep quality and duration. There was an improvement in FEV1 from admission to discharge (22%± 19 predicted, p =0.0002). There was no significant improvement between admission and discharge in any sleep parameters on actigraphy. There were also no significant changes to questionnaire results in sleep disturbance (p=0.6) or impairment (p = 0.8) from admission to discharge. Though lung function improved, inpatient treatment for pulmonary exacerbation did not affect sleep quality and duration in PwCF. Our findings suggest promoting good sleep habits during hospitalization.