Olfactory receptor (OR) proteins play a crucial role in insect olfactory systems, including Rhynchophorus ferrugineus (red palm weevil), a significant global pest of palm trees. A scarcity of structural data on its chemosensory proteins, especially ORs, complicates the development of targeted control strategies. In the rapidly evolving field of protein structure analysis, identifying reliable reference proteins and obtaining precise structural data remain major challenges. This study utilised high-throughput structural bioinformatics to identify and characterize OR proteins in Rhynchophorus ferrugineus. Analysis of 110 OR proteins revealed that RferOR18148 and RferOrco were significant targets. A comparison of the modelled OR structures with experimental crystal structures confirmed their accuracy. Motif analysis indicated high conservation among the OR proteins, reflecting their evolutionary significance. Molecular dynamics (MD) simulations confirmed the structural stability of RferOR18148 and RferOrco, which maintain their native conformations in a lipid membrane. The literature study further confirmed that proteins are expressed in chemosensory systems, reinforcing their roles as reference structures. These protein structures have been successfully identified and validated for future research on OR and chemosensory mechanisms. The findings offer new insights into the molecular mechanisms of chemosensory signalling in R. ferrugineus, laying the groundwork for pest management strategies through the modulation of chemosensory pathways. Additionally, our research presents a systematic approach for identifying target proteins involved in olfactory communication, serving as a basis for future virtual screening studies of potential inhibitors.