The CRISPR-Cas system has revolutionized gene editing and transcriptional regulation, yet its therapeutic and synthetic potential is limited by a lack of spatiotemporal control. Electrogenetics using electrical signals to modulate gene expression offers a dynamic, reversible, and non-invasive solution to this challenge. This review explores the integration of electrogenetic technologies with CRISPR platforms to enable externally controllable gene regulation. We discuss key molecular mechanisms, including ROS and calcium-mediated pathways, and highlight strategies for engineering electrically responsive CRISPR circuits using inducible promoters and modular components. Bioelectronic interfaces such as microelectrode arrays, conductive scaffolds, and implantable devices are reviewed for their roles in precise electrical stimulation. Applications in precision medicine, regenerative therapy, data storage, and environmental biosensing are examined, along with comparisons to other control modalities such as optogenetics and chemical inducers. We assess the benefits of electrogenetics in terms of depth of tissue penetration, programmability, and clinical integration. Finally, the review outlines challenges in biocompatibility and signal tuning, and explores future directions combining electrogenetics with artificial intelligence and cyber-physical systems. Together, these advances position electrogenetic-CRISPR systems as a foundation for intelligent, patient-specific gene therapies and programmable biointerfaces.