Autonomous Sensory Meridian Response (ASMR) is a pleasant feeling involving tingling sensations from the head to spine and other body parts, accompanied by relaxation, comfort, and slight euphoria. ASMR is most often stimulated when receiving personal attention in real life, or when receiving simulated personal attention from a video, which are often called “ASMR videos.” These ASMR videos are widely reported to increase or improve mood, focus, relaxation, and sleep, and may even help with the diagnosed conditions of anxiety, insomnia, and depression. Although not as studied as other conditions, ASMR may also related individuals with Attention Deficit Hyperactivity Disorder (ADHD). Our aim was to investigate ASMR videos’ effects on individuals with ADHD. Using eye tracking, skin conductivity response, and psychological scales, we examined physiological effects of ASMR in individuals with clinical ADHD diagnoses. Results revealed a highly significant positive correlation between ADHD and ASMR, depression, and anxiety. Although no significant differences in physiological outputs were found, our results suggest ASMR content consumption may be linked to the ADHD phenotype. This study is the first to investigate the relationship between ASMR and ADHD features in the general population and may guide future ASMR research in this area.