Climate change and rapid urbanization in African cities are intensifying environmental challenges, particularly rising temperatures and increasing levels of organic pollution. These stressors have significant but complex effects on bacterial behaviour and might be implicated in the development of antimicrobial resistance (AMR). This review synthesizes current research on the individual and combined impacts of temperature rise and emerging environmental organic contaminants (EEOCs) on bacteria and their role in AMR. Some key EEOC classes identified include pharmaceuticals, personal care products, and per-/poly-fluoroalkyl substances. Individually, EEOCs have been shown to impair bacterial growth and promote mutagenesis, while elevated temperatures enhance bacterial proliferation and increase genetic exchange mechanisms such as horizontal gene transfer. Although studies have illuminated these individual effects, little research has focused on their simultaneous and potentially synergistic interactions. This represents a critical gap in understanding the environmental drivers of AMR and their implications for public health. Moreover, these effects vary by climate zone and are influenced by regional infrastructure and environmental conditions. Understanding the nexus between temperature rise, organic pollution, and bacterial resistance is essential for predicting disease patterns and guiding mitigation strategies in rapidly urbanizing, climate-sensitive regions.