Glanzmann Thrombasthenia refers to autosomal recessive disorder of platelet aggregation caused by quantitative or qualitative defects in integrins αIIb and β3. Asymptomatic or presenting with [petechiae](https://next.amboss.com/us/article/_405NT), [purpura](https://next.amboss.com/us/article/_405NT), [epistaxis](https://next.amboss.com/us/article/Hj0KbT), [menorrhagia](https://next.amboss.com/us/article/G80BL3), gingival bleeding. In our study, the patient presents with unexplained bleeding at the site of vaccination, recurrent drop in hemoglobin and psychomotor retardation which was treated with managed conservatively with antifibrinolytic agents. This case underscores the importance of recognizing association between Glanzmann thrombasthenia and neurodevelopmental delayand, additionally the need for prompt intervention.