\documentclass[10pt]{article}

\usepackage{fullpage}
\usepackage{setspace}
\usepackage{parskip}
\usepackage{titlesec}
\usepackage[section]{placeins}
\usepackage{xcolor}
\usepackage{breakcites}
\usepackage{lineno}
\usepackage{hyphenat}





\PassOptionsToPackage{hyphens}{url}
\usepackage[colorlinks = true,
            linkcolor = blue,
            urlcolor  = blue,
            citecolor = blue,
            anchorcolor = blue]{hyperref}
\usepackage{etoolbox}
\makeatletter
\patchcmd\@combinedblfloats{\box\@outputbox}{\unvbox\@outputbox}{}{%
  \errmessage{\noexpand\@combinedblfloats could not be patched}%
}%
\makeatother


\usepackage{natbib}




\renewenvironment{abstract}
  {{\bfseries\noindent{\abstractname}\par\nobreak}\footnotesize}
  {\bigskip}

\titlespacing{\section}{0pt}{*3}{*1}
\titlespacing{\subsection}{0pt}{*2}{*0.5}
\titlespacing{\subsubsection}{0pt}{*1.5}{0pt}


\usepackage{authblk}


\usepackage{graphicx}
\usepackage[space]{grffile}
\usepackage{latexsym}
\usepackage{textcomp}
\usepackage{longtable}
\usepackage{tabulary}
\usepackage{booktabs,array,multirow}
\usepackage{amsfonts,amsmath,amssymb}
\providecommand\citet{\cite}
\providecommand\citep{\cite}
\providecommand\citealt{\cite}
% You can conditionalize code for latexml or normal latex using this.
\newif\iflatexml\latexmlfalse
\providecommand{\tightlist}{\setlength{\itemsep}{0pt}\setlength{\parskip}{0pt}}%

\AtBeginDocument{\DeclareGraphicsExtensions{.pdf,.PDF,.eps,.EPS,.png,.PNG,.tif,.TIF,.jpg,.JPG,.jpeg,.JPEG}}

\usepackage[utf8]{inputenc}
\usepackage[greek,english]{babel}



\usepackage{float}








\begin{document}

\title{~iMiLAB: A New~ Cassette-based Micro-fluidic Platform for PET
Radiotracer Synthesis -- Initial~ Results for the Synthesis of
{[}\textsuperscript{11}C{]}Methionine}



\author[1]{SRSTT Radiopharmaconnect}%
\affil[1]{Radiopharmaconnect}%


\vspace{-1em}



  
  \date{March 14, 2025}


\begingroup
\let\center\flushleft
\let\endcenter\endflushleft
\maketitle
\endgroup








\sloppy


\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/CAFACHEM1/CAFACHEM1}

\end{center}
\end{figure}

\textbf{Authors:~ Francesca Goudou}\textsuperscript{a,b,c}, Virginie
Hourtane\textsuperscript{b}, Nicolas Masse\textsuperscript{b}, Yahya
Cisse\textsuperscript{b}, Abdul Karim Haji Dheere\textsuperscript{c} and
Antony Gee\textsuperscript{c} \textbf{}

\textsuperscript{a} SYNBIOLAB -- Actualis Jarry, 44 rue Henry Becquerel
Jarry 97122 Baie-Mahault -- Guadeloupe.

\textsuperscript{b} PMB Head office -- France Route des Michels CD56, La
Corneirelle 13790 Peynier -- France.

\textsuperscript{c} School of Imaging Sciences and Biomedical
Engineering, King's College London, London, SE1 7EH, UK.

\par\null

\textbf{Background}

Microfluidic-based radiochemistry has several potential advantages for
radiotracer synthesis including accelerated reaction rates, simple
purification processes, high yields, high molar activities and one-use
disposability/ease of use\textsuperscript{1}. However, despite prompting
the interest of the scientific community, few of these systems have been
developed as commercially available products\textsuperscript{1}. \emph{}

\textbf{Aims}

A new microfluidic PET radio-synthesis system performance is underway.
{[}\textsuperscript{11}C{]}methionine is widely used in clinical PET for
imaging tumors~ and was therefore selected as one of the initial
radiotracers for iMiLAB proof-of concept studies\textsuperscript{2}.
Here we report the initial results for the synthesis of
{[}\textsuperscript{11}C{]}methionine.

\par\null

\textbf{Methods}

{[}\textsuperscript{11}C{]}CO\textsubscript{2} was produced by the
\textsuperscript{14}N (p, \selectlanguage{greek}α\selectlanguage{english})\textsuperscript{11}C reaction using 11.5~
MeV protons at 5 \selectlanguage{greek}µ\selectlanguage{english}A for 1.5 min. {[}\textsuperscript{11}C{]}CH3I was
produced by the gas phase method and delivered to react with
~L-homocysteine onto a C18 solid phase matrix embedded in a disposable
iMiLAB microfluidic.

\par\null

\textbf{Results and Conclusion}

The radiotracer was produced within 13 minutes with a radiochemical
purity of 99.9 \%. Initial
{[}\textsuperscript{11}C{]}CH\textsubscript{3}I flow rate studies
revealed an increase in radiochemical yield from 31 \% to 66 \% (decay
corrected to end of {[}\textsuperscript{11}C{]}CH\textsubscript{3}I
delivery) when the {[}\textsuperscript{11}C{]}CH\textsubscript{3}I flow
rate was reduced from 30 to 15 mL/min.

\textbf{References}

\textbf{1.} Z. Jian-ping, Z.Yong-ping, W.Ming-wei and Z. Ying-jian.
Chinese Journal of Nuclear Medicine and Molecular Imaging. 2012; 32: 315
-- 318.

\textbf{2.} F. Lodi, C. Malizia, P. Castelluci, G. Cicoria, S. Fanti and
S. Boschi. Nuclear Medecine and Biology. 2012; 39: 447 - 460.\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/2/2}

\end{center}
\end{figure}

\textbf{Scheme 1.} Schematic diagram of the microfluidic cassette used
in R\&D radio-synthesizer iMiLAB.

\textbf{{}}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/CAFACHEM/CAFACHEM}

\end{center}
\end{figure}

\selectlanguage{english}
\FloatBarrier
\end{document}

