\documentclass[10pt]{article}

\usepackage{fullpage}
\usepackage{setspace}
\usepackage{parskip}
\usepackage{titlesec}
\usepackage[section]{placeins}
\usepackage{xcolor}
\usepackage{breakcites}
\usepackage{lineno}
\usepackage{hyphenat}





\PassOptionsToPackage{hyphens}{url}
\usepackage[colorlinks = true,
            linkcolor = blue,
            urlcolor  = blue,
            citecolor = blue,
            anchorcolor = blue]{hyperref}
\usepackage{etoolbox}
\makeatletter
\patchcmd\@combinedblfloats{\box\@outputbox}{\unvbox\@outputbox}{}{%
  \errmessage{\noexpand\@combinedblfloats could not be patched}%
}%
\makeatother


\usepackage{natbib}




\renewenvironment{abstract}
  {{\bfseries\noindent{\abstractname}\par\nobreak}\footnotesize}
  {\bigskip}

\titlespacing{\section}{0pt}{*3}{*1}
\titlespacing{\subsection}{0pt}{*2}{*0.5}
\titlespacing{\subsubsection}{0pt}{*1.5}{0pt}


\usepackage{authblk}


\usepackage{graphicx}
\usepackage[space]{grffile}
\usepackage{latexsym}
\usepackage{textcomp}
\usepackage{longtable}
\usepackage{tabulary}
\usepackage{booktabs,array,multirow}
\usepackage{amsfonts,amsmath,amssymb}
\providecommand\citet{\cite}
\providecommand\citep{\cite}
\providecommand\citealt{\cite}
% You can conditionalize code for latexml or normal latex using this.
\newif\iflatexml\latexmlfalse
\providecommand{\tightlist}{\setlength{\itemsep}{0pt}\setlength{\parskip}{0pt}}%

\AtBeginDocument{\DeclareGraphicsExtensions{.pdf,.PDF,.eps,.EPS,.png,.PNG,.tif,.TIF,.jpg,.JPG,.jpeg,.JPEG}}

\usepackage[utf8]{inputenc}
\usepackage[T2A]{fontenc}
\usepackage[polish,english]{babel}



\usepackage{float}








\begin{document}

\title{Carbon-11 carboxylation of trialkoxysilane and trimethylsilane
derivatives using
{[}\textsuperscript{11}C{]}CO\textsubscript{2}~~~~~~~~~~~~~~~~~~~~}



\author[1]{SRSTT Radiopharmaconnect}%
\affil[1]{Radiopharmaconnect}%


\vspace{-1em}



  
  \date{April 25, 2024}


\begingroup
\let\center\flushleft
\let\endcenter\endflushleft
\maketitle
\endgroup








\sloppy


\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/CAFACHEM/CAFACHEM}

\end{center}
\end{figure}

\textbf{\href{https://www.srsweb.org/cafachem2020}{CAFACHEM~2020}}
organizers are grateful for the support
of\textbf{~\href{https://www.imigine.com/}{\textbf{PMB Alcen}}}

\par\null\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/PMB/PMB}

\end{center}
\end{figure}

\textbf{Authors:} Salvatore Bongarzone, Nicola Raucci, Igor Camargo
Fontana,~\textbf{Federico Luzi} and Antony D. Gee ~

King's College London, UK

\textbf{Background}

Traditional \textsuperscript{11}C-carboxylation from
{[}\textsuperscript{11}C{]}CO\textsubscript{2} is achieved by the use of
either Grignard reagents or boronic ester precursors, however presenting
limitations related to air and moisture sensitivity, functional group
tolerance, low RCYs and reproducibility.\textsuperscript{1,2}
Improvements on \textsuperscript{11}C-carboxylation could be achieved by
a copper-catalysed desilylative carboxylation reaction of trialkoxysilyl
and trimethylsilyl derivatives.\textsuperscript{3}

\textbf{Aims}

The development of a novel, one-pot and widely-applicable protocol for
\textsuperscript{11}C-carboxylation and
\textsuperscript{11}C-methylation involving the use of trimethylsilane
and trialkoxysilane derivatives to be achieved in short synthesis times,
with high molar activities and RCYs.

\textbf{Methods}

An aryltrimethylsilane or aryltrialkoxysilane derivative is initially
mixed with a fluoride source (KF-K2.2.2), a copper catalyst (CuI) and a
CO\textsubscript{2}-trapping agent (BEMP). The activated precursor~
reacts with {[}\textsuperscript{11}C{]}CO\textsubscript{2} or
{[}\textsuperscript{11}C{]}CH\textsubscript{3}I to yield the
{[}\textsuperscript{11}C{]}aryl carboxylate or
{[}\textsuperscript{11}C{]}tolyl derivative, respectively. This method
uses a simple one-vial, one-valve set-up.

\textbf{Results and Conclusion}

Six {[}\textsuperscript{11}C{]}carboxylic acids were obtained from their
corresponding trimethylsilyl and trialkoxysilyl precursors with RCYs up
to 93\% (non-isolated, estimated by radio-HPLC) within 12 minutes post
{[}\textsuperscript{11}C{]}CO\textsubscript{2} delivery.
\textsuperscript{11}C-methylation was achieved, as well, with a RCY of
16\%. This method represents a solid alternative in the radiolabelling
of {[}\textsuperscript{11}C{]}carboxylic acids and
{[}\textsuperscript{11}C{]}methylated aromatic rings.

\textbf{References}

\textbf{1.} Riss, P. J.; Lu, S.; Telu, S.; Aigbirhio, F. I.; Pike, V. W.
\emph{Angewandte Chemie International Edition} \textbf{2012}, \emph{51},
2698.

\textbf{2.} Peko\selectlanguage{polish}š\selectlanguage{english}ak, A.; Filp, U.; Rotteveel, L.; Poot, A. J.;
Windhorst, A. D. \emph{Journal of Labelled Compounds and
Radiopharmaceuticals} \textbf{2015}, \emph{58}, 342.

\textbf{3.} Yu, B.; Yang, P.; Gao, X.; Yang, Z. Z.; Zhao, Y. F.; Zhang,
H. Y.; Liu, Z. M. \emph{New Journal of Chemistry} \textbf{2017},
\emph{41}, 9250.\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/Screenshot-2020-07-10-at-12-27-15/Screenshot-2020-07-10-at-12-27-15}
\caption{{\textsuperscript{11}C-carboxylation and
\textsuperscript{11}C-methylation of arylsilyl precursors.
{\label{174873}}%
}}
\end{center}
\end{figure}

\textbf{}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/Screenshot-2020-07-10-at-12-20-47/Screenshot-2020-07-10-at-12-20-47}

\end{center}
\end{figure}

\selectlanguage{english}
\FloatBarrier
\end{document}

