Over the last several years, a group out of UCLA has been developing radiotracers for the sodium-glucose linked transporters (SGLTs). Methyl [18F]4-deoxy-4-fluoro-α-d-glucosepyranoside ([18F]Me-4FDG) is also a glucose derivative, but is a poor substrate for the GLUTs and has greater affinity for SGLT1 and SGLT2. Similar to [18F]FDG, [18F]Me-4FDG is effectively trapped intracellularly as it is not a substrate for further downstream metabolism and due to low rate of exit through SGLTs.