Background: Few studies exist on the functional connection network of key brain regions in the field of the central mechanism of pain management information. Methods: In this study, we aimed to investigate whether chronic pain is connected to abnormal network connectivity. A total of 28 participants with knee osteoarthritis (KOA) and 28 healthy controls were enrolled. Resting-state functional magnetic resonance imaging (rfMRI) was used to measure functional connection (FC) with the anterior cingulate cortex (ACC) as a seed point and degree of centrality (DC) in the brain regions of the two groups. Results: FC values increased in the right precentral gyrus, while DC values increased in the right precentral gyrus and opercular section of inferior frontal gyrus. Conclusions: Our analysis of brain-interconnect patterns suggests that chronic pain may be self-sustaining. Functional connectivity modulated the relationship between multiple dimensions of chronic pain by altering the relevant brain regions over time so that they reorganized and participated in functional remodeling.