Genomic imprinting is a form of epigenetic regulation that leads to expression from one parental allele only and, in animals, is unique to mammals. Imprinted gene expression is predominant in the brain and their roles in neural processes are becoming more appreciated. Recent analyses have indicated an enrichment of imprinted gene expression in the “parental hub” circuitry. Specifically, imprinted genes were over-represented in the transcriptomic profile of Galanin positive (Gal+) neurons in the medial preoptic area (MPOA) of the hypothalamus. One of those imprinted genes showing enriched expression in Gal+ neurons was the maternally expressed Asb4. Here, we hypothesise that Asb4 has a role in the function of the MPOA and influences parental behaviour. We aim to demonstrate abnormal parental behaviours and activity of MPOA Gal+ neurons in Asb4-brain specific knockout mice.