Introduction: The VASCADE MVP venous vascular closure system is used for rapid hemostasis in electrophysiology procedures. Methods and Results: Three pediatric patients who underwent electrophysiology study subsequently developed erythema, swelling, and tenderness of their femoral access site(s) between 5 days and 3 weeks after their procedure. The findings were thought to be secondary to an inflammatory response or infectious response to the VASCADE MVP collagen plugs. One case required removal of the collagen plugs while the other two improved with antibiotic treatment and delayed resorption of the vascular plug. Conclusion: As device-based vascular closure continues to be a favorable option compared to manual compression for electrophysiology studies, it is important to be mindful of potential post-procedural complications such as the described inflammatory or infectious response to the VASCADE MVP collagen plug in pediatric patients.