The background of Takotsubo cardiomyopathy is classically associated with identifiable emotional stress; however, there is a significant number of cases that meet the diagnostic criteria without any identifiable antecedent stress. While the literature reports cases of Takotsubo cardiomyopathy triggered by various factors such as emotional stress or physical stress, our case highlights a unique association between steroid and Takotsubo Cardiomyopathy (TCM). In this instance, we present a rare case involving a 72-year-old family patient with a medical history significant for immune thrombocytopenia (ITP) and coronary artery disease status post-stent placement in the left anterior descending artery 16 years ago in 2009. The patient presented with cardiac chest pain, and while cardiac catheterization ruled out coronary artery disease, the left ventricle gram strongly suggested Takotsubo cardiomyopathy, a diagnosis later confirmed by a surface echocardiogram. Interestingly, the patient denied recent catastrophic events causing stress but revealed that the patient was taking 40mg of dexamethasone for five days for ITP management.
