Background: Understanding patient’s attitudes towards deprescribing is important for implementation of deprescribing in practice. These attitudes may differ within a patient depending on the medication. Objective: To assess whether there are within-patient differences in attitudes towards deprescribing the following cardiovascular and diabetes medications: statins, antihypertensives, sulfonylureas and insulins. Methods: We administered the revised Patient Attitudes Towards Deprescribing questionnaire to Dutch primary care patients. The ‘appropriateness’ and ‘concerns’ subscales were adapted to measure medication-specific attitudes. Pairwise comparisons of unreversed appropriateness and concerns sum scores were tested with Wilcoxon signed-rank tests, and differences in underlying items were explored. Results: Out of 280 patients that completed the questionnaire, 160 patients (median age: 79 years, 34% frail) did so for at least two medication classes. Patients’ perceived deprescribing of their insulins less appropriate as compared to the other medication classes (all p<.031), and deprescribing sulfonylureas less appropriate as compared to antihypertensives (p=.036) or statins (p=.006). No differences were found for the concerns sum scores but differences were observed in underlying items. Conclusion: Patients were more positive towards deprescribing statins and antihypertensives as compared to sulfonylureas and particularly insulins. Healthcare providers should be aware that patients can experience medication-specific barriers when discussing options for deprescribing.