not-yet-known not-yet-known not-yet-known unknown Introduction Myoepithelial tumors are uncommon tumor with no specific predilection for age or sex. Myoepithelial tumors of the head and neck are predominantly found in the salivary glands, whereas those located in the sinuses are rare. 1,2A study observed that 66 (about0.009%) out of 7190 salivary gland tumors involved maxillary sinus, confirming its rarity in this anatomical location. 3We report a case of an older male patient with a lesion in the sphenoid sinus who was admitted to the hospital with decreased visual acuity. Preoperative computed tomography (CT) and magnetic resonance imaging (MRI) indicated a mass in the sphenoid sinus, and postoperative pathology confirmed the diagnosis. To our knowledge, there are no reports in the literature on myoepitheliomas located in the sphenoid sinus. Myoepitheliomas lack distinctive imaging, making preoperative diagnosis challenging. Consequently, diagnosis relies on postoperative pathology and immunohistochemistry. Surgery is currently an effective treatment modality; however, the efficacy of radiotherapy and chemotherapy remains unclear.