1.IntroductionThe most common causative agents in CNS infections are bacteria, accounting for 36.70%-63.20% of cases[1], with S.aureus being the most common, and fungal brain abscesses being less common in brain abscesses. Fungal brain abscesses are relatively rare in brain abscesses, accounting for 1.05%-2.38% of cases. Candida is one of the four common fungal genera. Candida is common in Candida albicans, and Candida glabrata (C. glabrata) brain abscesses are very rare[2-3]. Due to its extremely low incidence and lack of specific clinical manifestations and imaging features, the diagnosis of C. glabrata brain abscess is very difficult, and the lack of comprehensive and in-depth clinical and imaging knowledge of it makes it easy to misdiagnose it during diagnosis and treatment as a bacterial brain abscess or other diseases or the failure to choose the appropriate antibiotics in treatment. Based on its cytologic features, it can be diagnosed by cerebrospinal fluid pathogenesis. To the best of our knowledge, few articles have reported diffuse multiple critical C. glabrata brain abscesses. Here, we report a case of multiple C. glabrata brain abscess with typical lesion features of C. glabrata brain abscess on cranial Magnetic Resonance Imaging(MRI) and cranial MR contrast enhancement, which was confirmed by lumbar puncture cerebrospinal fluid pathogenesis.