Plantar warts are a skin problem of great importance due to their prevalence and their negative effects on the patient’s quality of life. Of all the treatments used, the combination cantharidin-podophyllin-salicylic acid (CPS) has shown greater efficacy than the others, although its combination with nitric acid has not been studied. The objective was to analyze the efficacy and safety of the combination of CPS with nitric acid in the first session with respect to the individualized components for the treatment of plantar warts. We analyzed the number of visits and treatment sessions, side effects and evaluated the influence of sex, age range, comparing the combination of SCP and nitric acid in the first session versus the two treatments separately in 196 patients. There were no differences in sex, with a higher incidence in children under 15 years of age. The type of wart was single (86.6%) with a mean size of 6.13 ± 2.91 mm and metatarsal location in 49%. The first visit CPS-nitric acid combination resulted in a mean number of visits of 3.7±2.8, a mean of 2.5±2.9 applications and 45±23 days for lesion resolution, shorter time compared with individualized treatments. A complete resolution was observed in 96.4% of patients treated. The majority side effect was pain (65.5%) with low level on VAS scale (49.7%). In conclusion, the CPS-nitric acid combination was a very high effective treatment for plantar warts with a very fast and high rate for lesions resolution.