Osteoporosis is gradually becoming a disease with global importance and is one of the most commonly neglected diseases among various populations. Many studies of osteoporosis rely on calcium and inorganic salt levels in the bone structure and microenvironment as measures of osteoporosis. Here, we discuss N6-methyladenosine (m6A) and osteoporosis with novel insight into the pathogenesis of osteoporosis. The m6A modification is a posttranscriptional epigenetic modification and has been shown often to participate in the modification of mRNAs and noncoding RNAs (ncRNAs). The m6A influences the fate of RNA molecules and affects almost all bioprocesses, such as the development of cancer and other disorders. Accumulating evidence has shown that ncRNAs that cooperate with m6A and participate in the regulation of bioprocesses related to osteoporosis. This systematic review summarizes the latest studies on the expression of m6A and ncRNAs and their roles in osteoporosis.