IntroductionLow-dose oral minoxidil (LDOM) has gained popularity as an off-label treatment for androgenetic alopecia due to its efficacy and convenience compared to topical formulations. While commonly reported side effects include hypertrichosis, edema, and dizziness, the literature does not clearly document xerostomia as an adverse effect [1]. We report a case of severe dry mouth in an elderly patient treated with 0.5 mg/day of oral minoxidil. To our knowledge, this is the first reported case of xerostomia associated with low-dose oral minoxidil, confirmed by symptom recurrence upon re-exposure. It highlights the need to consider dry mouth among potential systemic adverse effects of minoxidil, particularly as its dermatologic use becomes more widespread.