This paper describes the diagnosis, treatment and outcome of a filly with disseminated pyomyositis and septic arthritis of the left scapulohumeral joint, secondary to omphalourachitis caused by Salmonella sp. On physical exam, omphalopathy, lameness and increased fluctuating and hyperechogenic volume of both deltoid and triceps brachii muscles were identified. Surgical removal of the umbilical remnants, drainage of the muscle abscesses and clinical treatment were performed. Due to the rare location, the septic arthritis consequences and the disseminated pyomyositis unresponsive to treatment, its poor prognosis referred the patient to euthanasia. Postmortem findings confirmed purulent and hemorrhagic pyomyositis and septic scapulohumeral arthritis with fractured areas. This rare report highlights that Salmonella sp. can occur extra-enterically, such as in the umbilical remnants, muscles and scapulohumeral joint. Complications resulting from hematogenous dissemination of Salmonella sp. reinforce that early and aggressive treatment of omphalourachitis is essential. In vivo bacterial resistance should be considered.