The COVID-19 pandemic exposed vulnerabilities in global healthcare systems while highlighting the potential of digital interventions to enhance crisis preparedness and response. In India, various digital interventions became crucial for improving healthcare delivery and optimizing the production, transportation, safe storage, and efficient distribution of medical oxygen- a critical resource during the pandemic. This study investigates the role of digital interventions in managing medical oxygen efficiently during the pandemic through an extensive literature review, secondary data analysis, and semi-structured interviews with key stakeholders in the oxygen ecosystem. The findings propose a framework based on elements from the ‘Penchansky Model of Access’—Availability, Accessibility, and Affordability—along with additional dimensions of Accountability, Implementation, and Scalability These dimensions are further categorized under three scenarios: Conventional, Contingency, and Crisis. The results offer valuable insights for policymakers and healthcare providers on the effectiveness of digital initiatives in managing oxygen supply during public health emergencies.