Background: 650,000 people died from AIDS-related illnesses worldwide in 2021. Opportunistic infections (OIs) are occurring more frequently and with progressive severity among the people infected with the Human Immunodeficiency Virus (HIV) with wide variation based on epidemiological area. Objectives: To evaluate the distribution of opportunistic infections among the patients undergoing ART and various drug use indicators, utilization patterns, interactions, adverse effects of the drugs among the patients with OIs, undergoing ART. Methodology: Ambispective study. The present study included 424 patients diagnosed with retroviral disease and on treatment at the ART center, RRMCH. Demographic data, viral load, blood investigations, and presenting complaints at each follow-up were assessed. Results: The Average age of our study population was 42.85 years, with male predominance. 4.7% (20/424) of the patients with OI had poor adherence. 89% are alive, 5% died during treatment. The rest had transferred out. 41.7% (48/115) presenting with tuberculosis was the commonest opportunistic infection, and thus, the anti-TB drugs were the most frequent drugs used. Conclusion: Management of opportunistic infections regularly is one of the crucial exploratory tools to determine the role of drugs and their changing trend; there has been a reduction in CD4 count even with newer ART drugs, and hence, the OIs.
