Salt and drought represent major threats to global agricultural productivity and food security, but plants have developed a suite of adaptive responses conferring short-or longer-term survival to this stress. A new transcription factor HgMYB60 in H. glomeratus was explored to coordinate these responses. We cloned the full-length sequence of HgMYB60, determined the expressions and functions of HgMYB60, and explored the HgMYB60 assayed proteins related to sodium and potassium transport. The expression levels of HgMYB60 were increased in Arabidopsis mutants under salt and drought stress, and HgMYB60-overexpressing Arabidopsis mutants showed enhanced survival to salt and drought stress. In addition, HgMYB60 mediated sodium ion efflux and potassium ion absorption at the cellular level. HgMYB60 was localized to the nucleus, and these results are thus consistent with a major role for Na + transport in the signaling systems that respond to salt and drought stress.