We presented a pedigree of familial cerebral cavernous malformation with the pathogenic mutation of KRIT1 gene: NM_194456.1: c.1630delT(p.Tyr544Ilefs*8). The mutation site located at exon16/CDS12 in chr7:91844025-91844025. The proband had paroxysmal dizziness and sluggish reaction except for common manifestations, and subsequently received surgical treatment with a favourable prognosis. In recent years, mutations