Schizophyllum commune (SC) has garnered increasing attention in the medical field due to its capacity to cause a variety of infections in humans. This review provides a comprehensive overview of the epidemiological characteristics, clinical features, and diagnostic approaches for SC infections. This opportunistic pathogen predominantly affects immunocompromised individuals, particularly those with underlying hematological malignancies or organ transplantation. The clinical manifestations of SC infections can range from localized sinusitis to disseminated and potentially life-threatening conditions. Epidemiological investigations indicate that is a ubiquitous fungus, widely distributed in the environment. However, in immunocompromised individuals, this fungus can lead to serious infections, such as rhinosinusitis, cutaneous lesions, and disseminated disease. Accurate diagnosis can be challenging, as the clinical presentation may resemble that of other fungal or bacterial pathogens. The development of advanced diagnostic techniques, including molecular identification through DNA sequencing and sensitive antigen detection assays, has significantly improved the ability to detect pathogenic fungi.